Non-steroidal anti-inflammatory drugs (NSAIDs) and traditional disease modifying antirheumatic drugs (DMARDs) are widely used in the treatment of psoriatic arthritis (PsA), but this is based more upon clinical experience than adequate evidence from clinical trials. This report summarises the results from available trials highlighting evidence of efficacy and deficiencies with respect to effect ...

OBJECTIVES To offer a second opinion on the recently published retrospective diagnosis of Cardinal Carlo de' Medici (1596-1666), a prominent member of the grand ducal family then ruling Tuscany. METHODS Retrospective diagnosis of historical figures is difficult and at times controversial, even with modern technology. It is based on contemporaneous medical descriptions and historical reviews, ...

Psoriatic arthritis occurs in 5 - 42% of patients with psoriasis. It is an inflammatory arthritis distinct from rheumatoid, being usually sero-negative, asymmetrical and often affecting the spine, sacro-iliac and distal interphalangeal joints. It runs a very variable course, from a mild non-destructive disease to a severe rapidly progressive erosive arthropathy, producing an 'arthritis mutilans...

Psoriatic arthritis (PsA) is defined as a heterogeneous inflammation correlating with psoriasis, usually sero-negative inflammatory arthropathy and the factor genes essential for its expression prediction. Therefore, current study aimed to determination whether IL-1β gene has role in development of psoriatic arthritis. A total (128) individual participated this study, (59) (29) others arthritis...

Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis. Traditional disease modifying anti-rheumatic drugs (DMARDs) have shown inconsistent and unsatisfactory results. Treatment with biological agents has shown different results. Despite the evident efficacy of biologic agents for psoriasis and psoriatic arthritis, there is an increase in psorias...

Psoriatic arthritis is an inflammatory arthropathy associated with the characteristic dermatologic lesions of psoriasis. The diagnosis of psoriatic arthritis is quite difficult, due to the overlap of patients with osteoarthritis (OA) or rheumatoid arthritis (RA) with concomitant non-associated psoriasis. A nonspecific elevation in inflammatory markers (erythrocyte sedimentation rate, ESR; antin...

OBJECTIVE The aim of the study is to describe a group of patients with a highly destructive and asymptomatic form of psoriatic arthritis, mimicking a Charcot-like joint disease. METHODS We studied 180 patients with psoriatic arthritis and identified 4 patients with arthritis mutilans mimicking a Charcot-like joint disease. Clinical history, physical exam, and immunological testing were perfor...

Objectives: This study aimed to reveal the genetic background of patients in two-generation family suffering from rheumatoid arthritis, psoriatic arthropathy pain, scratches, and bruises. Patients methods: A clinical exome sequencing analysis was performed 10 individuals same using Sophia Genetics solution kit. Results: novel V194L mutation TMEM173 gene identified three members family. Two were...

Arthropathy is one of the most prevalent diseases, which are based on destruction and remodeling cartilage bone tissue. The inflammation that precedes can be caused by mechanical stress joints, or autoimmune reactions. Recently, IL-7 considered as key cytokines promote production matrix metalloproteinases, catabolic enzymes, T cell-mediated activation monocytes, maturation osteoclasts. soluble ...