296 How to cite this article: Tateishi C, Imanishi H, Nimmannitya K, Tsuruta D. Ustekinumab successfully treated a patient with severe psoriasis vulgaris with primary failure to infliximab and secondary failure to adalimumab. Our Dermatol Online. 2015;6(3):296-298. Submission: 26.02.2015; Acceptance: 10.06.2015 DOI:10.7241/ourd.20153.79 Ustekinumab successfully treated a patient with severe pso...

Linear psoriasis is an uncommon skin disease of so far unknown origin.' Although many cases reported in the past under this diagnosis should today be reclassified as examples ofinflammatory linear verrucous epidermal naevus,2 or as psoriasis superimposing an epidermal naevus,3 there still remain a number of observations that undoubtedly represent true linear psoriasis. 1 4 5 To explain this unu...

Ocular manifestations in patients with psoriasis vulgaris have been investigated in only a small number of studies. Our purpose was to identify tear film function and ocular pathologies associated with psoriasis vulgaris in patients who had received neither oral retinoids nor phototherapy. We examined 62 eyes of 31 patients with psoriasis and 60 eyes of 30 age-and-sex matched healthy volunteers...

Geographic tongue (GT) and fissured tongue (FT) are the more frequent oral lesions in patients with psoriasis. The aims of this study were to compare the prevalence of GT/FT between psoriasis group (PG) and healthy controls (HC) and investigate the correlation between GT/FT and psoriasis severity using the PASI and age of psoriasis onset. Three hundred and forty-eight PG and 348 HC were selecte...

BACKGROUND We present an extremely rare case of tubo-ovarian abscesses involving Corynebacterium striatum (C. striatum) as causative agent in a 53-year-old woman. CASE PRESENTATION The patient presented with stomach pain, chills, and nausea. Her medical history included poorly controlled psoriasis vulgaris and diabetes. Laboratory and imaging findings led to diagnosis of septic shock due to t...

Background: Psoriasis is a chronic inflammatory T-cell-mediated skin disease, with a preponderance of type 1 cytokines that contribute in the induction and persistence of the inflammatory process. Leptin, a peptide hormone secreted mainly from the adipocytes of white fat is known to regulate a wide range of biological responses. Recently, leptin has been considered a cytokine -like hormone that...

BACKGROUND Soluble CD200 (sCD200) is a novel immuno-effective molecule, which acts to regulate inflammatory and acquired immune responses. Recently, our study group showed that sCD200 was present in serum and blister fluid in a patient with bullous pemphigoid and a patient with toxic epidermal necrolysis. We therefore planned this study to evaluate the sCD200 levels of autoimmune and inflammato...

OBJECTIVE To determine whether the three common independent sequence variants of the putative pleiotropic non-MHC autoimmune gene CARD15 influence disease susceptibility in large German cohorts of patients with psoriatic arthritis and psoriasis vulgaris, before and after stratification to HLA-C. METHODS DNA was obtained from 375 patients with psoriatic arthritis, 281 patients with psoriasis v...

Psoriasis vulgaris is a chronic inflammatory disease that classically affects skin and joints and is associated with numerous comorbidities. There are several clinical subtypes of psoriasis including the uncommon pustular variants, which are subdivided into generalized and localized forms. Generalized forms of pustular psoriasis include acute generalized pustular psoriasis, pustular psoriasis o...

GPP: generalized pustular psoriasis IL-36RN: interleukin-36 receptor antagonist PV: psoriasis vulgaris INTRODUCTION Generalized pustular psoriasis (GPP) is a rare but serious inflammatory skin disease that may be caused by deficiency of interleukin-36 receptor antagonist in which there is presence of homozygous or compound heterozygous mutations of the IL-36RN gene. Most GPP cases are sporadic,...