Cutaneous abnormalities in patients with end-stage renal disease (ESRD) receiving hemodialysis or peritoneal dialysis may demonstrate signs of their underlying condition or reveal associated disease entities. While a thorough examination of the scalp, skin, mucosa, and nails is integral to establishing a diagnosis, certain conditions will resolve only with dialysis or improvement of their renal...

Pseudoporphyria (PP) is characterized by skin fragility, blistering and scarring in sun-exposed skin areas without abnormalities in porphyrin metabolism. The phenylpropionic acid derivative group of nonsteroidal anti-inflammatory drugs, especially naproxen, is known to cause PP. Naproxen is currently one of the most prescribed drugs in the therapy of juvenile idiopathic arthritis (JIA). The pre...

756 CMAJ, July 14, 2015, 187(10) ©2015 8872147 Canada Inc. or its licensors A 26-year-old woman presented to the emergency department with a painful blistering eruption on her hands. She had been squeezing limes and lemons while making sangria the previous day. She had spent the rest of the day outdoors in the sun without sunscreen. Hours later, she experienced a painful burning erythema follow...

BACKGROUND Bullosis diabeticorum (BD) is a condition characterized by recurrent, spontaneous, and non-inflammatory blistering in patients with poorly controlled diabetes mellitus. While etiopathogenesis remains unclear, roles of neuropathy, vasculopathy and UV light are hypothesized. Most literature reports negative direct and indirect immunofluorescence findings in diabetics with bullous erupt...

are the frequently reported side effects, adverse cutaneous reactions are extremely rare. There are a few reports of acute generalized exanthematous pustulosis caused by faropenem and meropenem. However, bullous skin eruptions have not been reported, yet the various types of bullous drug reactions are bullous fixed drug reactions (FDRs), Stevens–Johnson syndrome and toxic epidermal necrolysis, ...

Nabumetone is a nonacidic nonsteroidal anti-infl ammatory drug (NSAID) formulated as a pharmacologically inactive prodrug that becomes active only after absorption, predominantly in the small intestine, and through hepatic conversion to its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA). This metabolite is structurally similar to naproxen, and is a potent inhibitor of prostaglandin ...

The porphyrias are metabolic disorders caused by altered activity of enzymes in the heme biosynthetic pathway. Porphyria cutanea tarda (PCT) is the most common subtype, with a prevalence of about 1 in 10,000 people,1 and is due to deficient activity of uroporphyrinogen decarboxylase (UROD), the fifth enzyme in the heme biosynthetic pathway. Cutaneous findings are common and include photosensiti...