نتایج جستجو برای: proviruses

تعداد نتایج: 963  

Journal: :PLoS Genetics 2007
Patric Jern Jonathan P Stoye John M Coffin

The ability of human and murine APOBECs (specifically, APOBEC3) to inhibit infecting retroviruses and retrotransposition of some mobile elements is becoming established. Less clear is the effect that they have had on the establishment of the endogenous proviruses resident in the human and mouse genomes. We used the mouse genome sequence to study diversity and genetic traits of nonecotropic muri...

Journal: :Cell 1998
Roswitha Löwer Ralf R Tönjes Klaus Boller Joachim Denner Bernd Kaiser Robert C Phelps Johannes Löwer Reinhard Kurth Klaus Badenhoop Horst Donner Klaus Henning Usadel Thomas Miethke Matthias Lapatschek Hermann Wagner

patients. Here we present findings contradicting this intriguing hypothesis. Autoimmunity and Transplantation Division The Walter and Eliza Hall The Endogenous IDDMK 1,2 22 Provirus Is Not a Novel Retrovirus Institute of Medical Research Royal Melbourne Hospital HERV-K is an endogenous retrovirus family of old world monkeys and humans with homologies to type B and Parkville 3050 Australia D ret...

Journal: :Journal of virology 2003
Nancy L DiFronzo Marisa Frieder Scott A Loiler Quynh N Pham Christie A Holland

The ability of mink cell focus-inducing (MCF) viruses to induce thymomas is determined, in part, by transcriptional enhancers in the U3 region of their long terminal repeats (LTRs). To elucidate sequence motifs important for enhancer function in vivo, we injected newborn mice with MCF 1dr (supF), a weakly pathogenic, molecularly tagged (supF) MCF virus containing only one copy of a sequence tha...

Journal: :Proceedings of the National Academy of Sciences 2020

Journal: :Journal of virology 1985
F Moreau-Gachelin J Robert-Lezenes F Wendling A Tavitian P Tambourin

Using the Southern blot procedure, we studied the presumed spleen focus-forming virus (SFFV) provirus integration sites in the genome of the premalignant and the malignant cells isolated during the course of Friend erythroleukemia. Two restriction endonucleases, PstI and BamHI, discriminated the presumed integrated SFFV proviruses from the endogenous xenotropic-mink cell focus-forming viral seq...

2012
Filip Šenigl Miroslav Auxt Jiří Hejnar

The autonomous transcription of integrated retroviruses strongly depends on genetic and epigenetic effects of the chromatin at the site of integration. These effects are mostly suppressive and proviral activity can be finally silenced by mechanisms, such as DNA methylation and histone modifications. To address the role of the integration site at the whole-genome-scale, we performed clonal analy...

Journal: :Journal of virology 2013
Khanh Soliven Xiaoxing Wang Christopher T Small Mostafa M Feeroz Eun-Gyung Lee Karen L Craig Kamrul Hasan Gregory A Engel Lisa Jones-Engel Frederick A Matsen Maxine L Linial

Simian foamy viruses (SFV) are complex retroviruses that are ubiquitous in nonhuman primates (NHP) and are zoonotically transmitted to humans, presumably through NHP saliva, by licking, biting, and other behaviors. We have studied SFV in free-ranging rhesus macaques in Bangladesh. It has been previously shown that SFV in immunocompetent animals replicates to detectable levels only in superficia...

2016
Kirston Barton Bonnie Hiener Anni Winckelmann Thomas Aagaard Rasmussen Wei Shao Karen Byth Robert Lanfear Ajantha Solomon James McMahon Sean Harrington Maria Buzon Mathias Lichterfeld Paul W. Denton Rikke Olesen Lars Østergaard Martin Tolstrup Sharon R. Lewin Ole Schmeltz Søgaard Sarah Palmer

The 'shock and kill' approach to cure human immunodeficiency virus (HIV) includes transcriptional induction of latent HIV-1 proviruses using latency-reversing agents (LRAs) with targeted immunotherapy to purge infected cells. The administration of LRAs (panobinostat or vorinostat) to HIV-1-infected individuals on antiretroviral therapy induces a significant increase in cell-associated unspliced...

Journal: :Journal of virology 2013
Magda Matousková Pavel Vesely Petr Daniel Giada Mattiuzzo Ralph D Hector Linda Scobie Yasuhiro Takeuchi Jirí Hejnar

Porcine endogenous retroviruses (PERV) represent a major safety concern in pig-to-human xenotransplantation. To date, no PERV infection of a xenograft recipient has been recorded; however, PERVs are transmissible to human cells in vitro. Some recombinants of the A and C PERV subgroups are particularly efficient in infection and replication in human cells. Transcription of PERVs has been describ...

2017
Anni Winckelmann Kirston Barton Bonnie Hiener Timothy E. Schlub Wei Shao Thomas A. Rasmussen Lars Østergaard Ole S. Søgaard Martin Tolstrup Sarah Palmer

OBJECTIVE To investigate the origin of the HIV-1 viremia induced by the latency-reversing agent romidepsin. DESIGN Six individuals on suppressive antiretroviral therapy received romidepsin administered intravenously once weekly for 3 consecutive weeks. CD4 T cells were obtained at baseline, following the second and third romidepsin infusion, and 10 weeks after the final romidepsin treatment. ...

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