In depth Monte Carlo conformational scans in combination with molecular dynamics (MD) simulations and electronic structure calculations were applied in order to study the molecular recognition process between tetrasubstituted naphthalene diimide (ND) guests and G-quadruplex (G4) DNA receptors. ND guests are a promising class of telomere stabilizers due to which they are used in novel anticancer...

Discs excised from Solanum tuberosum L. cv White Rose tubers demonstrated a 4.5-fold increase in chorismate mutase activity 48 hours after excision. Incubation in the presence of cycloheximide (25 micromolar) or actinomycin D (100 micromolar) completely inhibited the wound response suggesting de novo synthesis of chorismate mutase. Ratios of activity in the presence of the activator tryptophan ...

the dependence on ionic strength of protonation of l-aspartic acid and its complexation withdioxouranium(vi) is reported in sodium perchlorate solution as a background salt. the measurementshave been performed at 25 ± 0.1 °c and various ionic strengths in the range 0.1 to 1.0 mol dm-3, using acombination of potentiometric and spectrophotometric techniques. the overall analysis of the present an...

the protonation of different species of glycylisoleucine were studied in the ph range of 1.5 - 10 at25 °c using potentiometric technique. investigations were performed in sodium perchlorate andtetraethylammonium iodide as background electrolytes at i (0.1, 0.2, 0.3, 0.4, 0.5, and 0.6) moldm-3. the parameters based on the protonation constants were calculated, and their dependenceson ionic stren...

The dependence on ionic strength of protonation of L-aspartic acid and its complexation withdioxouranium(VI) is reported in sodium perchlorate solution as a background salt. The measurementshave been performed at 25 ± 0.1 °C and various ionic strengths in the range 0.1 to 1.0 mol dm-3, using acombination of potentiometric and spectrophotometric techniques. The overall analysis of the present an...

dl-Tryptophan (benzene ring-(14)C) and its metabolites persist longer and in greater quantity in tissues of endotoxin-poisoned mice than in tissues of normal mice. Correspondingly less label is excreted in urine and feces and expired as (14)CO(2) in the poisoned animals. The distribution of label (1.1 x 10(6) dpm per microgram of tryptophan) was relatively constant whether it was administered a...

L-Tryptophan and some of its analogues were previously observed to bind predominately at one site on human serum albumin (1). The unique nature of this site which favors the binding of L-tryptophan with an association constant 100 times greater than n-tryptophan made it seem worthwhile to investigate the entropy, enthalpy, and free energy changes accompanying the association at this site. In ad...

The protonation constants of glycine, L-alanine, glycyl-glycine, glycyl-glycyl-glycine and glycyl-L-alanine have been determined in 10-80% (v/v) ethanol-water mixtures at 25 °C and constant ionic strength (0.1 mol L-1 sodium perchlorate), by potentiometric technique and calculated using a suitable computer program, which employs a nonlinear least-squares method. The effect of solvent compositio...