PURPOSE To determine the significance of Ki-67/MIB1 staining as a marker of patient outcome for prostate cancer patients treated with radiotherapy. EXPERIMENTAL DESIGN Pretreatment archival prostate biopsy tumor tissue was available from 106 stage T1-T4 prostate cancer patients treated with external beam radiotherapy between 1987 and 1993 at M. D. Anderson Cancer Center. Diagnosis was made fr...

background and objective: non-specific granulomatous prostatitis is an uncommon diffuse inflammatory condition of the prostate. it is important because it may be mistaken for prostatic carcinoma. the aim of the study was to determine the prevalence of non-specific granulomatous prostatitis (nsgp) and comparing the results of transrectal ultrasonography, serum prostate specific antigen (psa) and...

BACKGROUND Prostate cancer diagnosis is routinely made by the histopathological examination of formalin fixed needle biopsy specimens. Frequently this is the only cancer tissue available from the patient for the analysis of diagnostic and prognostic biomarkers. There is, therefore, an urgent need for methods that allow the high-throughput analysis of these biopsy samples using immunohistochemic...

N. Hata, P. Blumenfeld, S. DiMaio, K. Zou, S. Haker, C. M. Tempany Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States INTRODUCTION Magnetic Resonance Image-guided prostate biopsy provides an alternative approach to detect and diagnose prostate cancer (1-3). The biopsies targeted at suspected tumor foci, observed in 1.5T and/or 0.5T pre-procedural image...

The reported detection rate of prostate cancer, lesions suspicious for cancer, and prostatic intraepithelial neoplasia (PIN) in needle biopsies is highly variable. In part, technical factors, including the quality of the biopsies, the tissue processing, and histopathological reporting, may account for these differences. It has been thought that standardisation of tissue processing might reduce ...

A technique for transperineal high-dose-rate (HDR) prostate brachytherapy and needle biopsy in a standard 1.5 T MRI scanner is demonstrated. In each of eight procedures (in four patients with intermediate to high risk localized prostate cancer), four MRI-guided transperineal prostate biopsies were obtained followed by placement of 14-15 hollow transperineal catheters for HDR brachytherapy. Mean...

Sir, The inaugural American Urologic Association (AUA) Quality Improvement Summit on January 25, 2014 introduced the directive to compile a white paper on the incidence, prevention, and treatment of complications related to prostate needle biopsy. We believe this summit brings to the urologic community’s attention the critical fact that published guidelines in antibiotic prophylaxis do not refl...

Numerous studies have demonstrated the efficacy of image-guided needle-based therapy and biopsy in the management of prostate cancer. The accuracy of traditional prostate interventions performed using transrectal ultrasound (TRUS) is limited by image fidelity, needle template guides, needle deflection and tissue deformation. Magnetic Resonance Imaging (MRI) is an ideal modality for guiding and ...

PURPOSE To quantify needle placement accuracy of magnetic resonance image (MRI)-guided core needle biopsy of the prostate. MATERIALS AND METHODS A total of 10 biopsies were performed with 18-gauge (G) core biopsy needle via a percutaneous transperineal approach. Needle placement error was assessed by comparing the coordinates of preplanned targets with the needle tip measured from the intrapr...