A program is described for automatically generating schematic linear representations of protein chains in terms of their structural domains. The program requires the co-ordinates of the chain, the domain assignment, PROSITE information and a file listing all intermolecular interactions in the protein structure. The output is a PostScript file in which each protein is represented by a set of lin...

A probabilistic regular motif language for protein sequences is evaluated. SRE-DNA is a stochastic regular expression language that combines characteristics of regular expressions and stochastic representations such as Hidden Markov Models. To evaluate its expressive merits, genetic programming is used to evolve SRE-DNA motifs for aligned sets of protein sequences. Different constrained grammat...

MOTIVATION A tool that simultaneously aligns multiple protein sequences, automatically utilizes information about protein domains, and has a good compromise between speed and accuracy will have practical advantages over current tools. RESULTS We describe COBALT, a constraint based alignment tool that implements a general framework for multiple alignment of protein sequences. COBALT finds a co...

MOTIVATION The detection of function-related local 3D-motifs in protein structures can provide insights towards protein function in absence of sequence or fold similarity. Protein loops are known to play important roles in protein function and several loop classifications have been described, but the automated identification of putative functional 3D-motifs in such classifications has not yet b...

We present in this article a fast approximate method for computing the statistics of a number of non-self-overlapping matches of motifs in a random text in the nonuniform Bernoulli model. This method is well suited for protein motifs where the probability of self-overlap of motifs is small. For 96% of the PROSITE motifs, the expectations of occurrences of the motifs in a 7-million-amino-acids r...

Wie schon erwähnt, wollen wir an den Prosite Daten das automatische Update unserer In-house Datenbank erproben. Erstellen Sie dazu zuerst ein relationales Schema, um die Daten in unsere bestehende Datenbank zu integrieren. Von den Prosite Daten sollen nur die Einträge gespeichert werden, die Pattern enthalten. Laden Sie die Daten und beantworten Sie einige Fragen. Um nun immer aktuelle Daten in...

Pattern matches for each of the sequence patterns in PROSITE, a database of sequence patterns, were searched in all protein sequences in the Brookhaven Protein Data Bank (PDB). The three-dimensional structures of the pattern matches for the 20 patterns with the largest numbers of hits were analysed. We found that the true positives have a common three-dimensional structure for each pattern; the...