In skin and hair research drug targeting to the hair follicle is of great interest. Therefore the influence of permeant lipophilicity and vehicle composition on local accumulation has been examined using confocal laser scanning microscopy (CLSM). Formulations saturated with either Oregon Green 488, Bodipy FL C(5) or Bodipy 564/570 C(5) were prepared. The dyes were applied in citric acid buffer,...

The effect of i.v. propylene glycol in doses of 160-800 mg kg-1 on heart rate, arterial pressure and efferent sympathetic activity were observed in anaesthetized paralysed, artificially ventilated dogs. Within 3-5 s of the commencement of the injection of propylene glycol there was an immediate mean decrease in heart rate of 22.7 and 72.1 beat min-1 and in arterial pressure of 27.2 and 58.8 mm ...

OBJECTIVES We evaluated the effect of naproxen sodium on propylene glycol-induced otitis media in guinea pig ears. MATERIALS AND METHODS Twenty adult guinea pigs were randomized to the study and control groups equal in number. A single dose of propylene glycol (0.2 ml, 60%) was applied to the left ears of the control group and to both ears of the study group. Saline solution was applied to th...

BACKGROUND A shisha-pen is an electronic cigarette variant that is advertised to mimic the taste of a water pipe, or shisha. The aim of this study was to assess the potential harmful health effects caused by inhaling the vapor of a nicotine-free shisha-pen. METHODS Gas chromatography analysis was performed to determine the major components in shisha-pen vapor. Risk assessment was performed us...

The objective of this study was to determine the effect of a sustained propylene glycol administration to recipients of frozen/thawed in vivo derived bovine embryos. Heifers were treated with oral propylene glycol for the last 20 days before embryo transfer (n = 142), and untreated as controls (n = 133). Progesterone, insulin, insulin-like growth factor-I, glucose, urea and triglyceride were an...

background compounds present in green tea have proved to inhibit the growth and activity of bacteria associated with infections. objectives to assess the effects of green tea leaves extract in presence of propylene glycol on the aerobic mouth bacteria load. materials and methods saliva of 25 volunteer girl students aging 20-25 years were selected and evaluated by a mouthwash sample containing 1...

the effects of monesin and propylene glycol on feed intake, milk production, and composition as well as some blood metabolites of 16 primiparous and multiparous holstein lactating cows (60±30 days in milk (dim), milk production of 33±3 kg/day) were evaluated. cows were experimentally in a arranged in a randomized complete block design of: 4 feeding treatments, and 2 blocks of either primiparous...

thin bonded films have many applications in antireflection and reflection coating, insulating and conducting films and semiconductor industries. thermal conductivity is one of the most important parameter for power packaging since the thermal resistance of the interconnections is directly related to the heat removal capability and thermal management of the power package. the defects in material...

A device for automatically maintaining any desired concentration of triethylene or propylene glycol vapor in air is described. It can also be used to measure very rapidly the glycol content of room air. This instrument should greatly facilitate tests of the efficacy of glycol vapors in preventing air-borne infections.