in this paper, the photocatalytic degradation of lidocaine hcl, an anesthetic was investigated inaqueous solution using cuo/zno as a photocatalyst. the degradation was studied under differentconditions including the amount of the photocatalyst, irradiation time, initial concentration of drug,ph of the system, initial concentration, addition of oxidant on the reaction rate and anion presence.the...

Objective : The anti-tumor effect of the beta-adrenergic receptor antagonist propranolol in breast cancer is well known; however, its activity glioblastoma not well-evaluated. Notch-Hes pathway known to regulate cell differentiation, proliferation, and apoptosis. We investigated human lines, role Notch Hes signaling this process.Methods performed immunohistochemical staining on 31 surgically re...

The aim of the present investigation was to formulate thermally sintered floating tablets of propranolol HCl, and to study the effect of sintering conditions on drug release, as well as their in vitro buoyancy properties. A hydrophilic polymer, polyethylene oxide, was selected as a sintered polymer to retard the drug release. The formulations were prepared by a direct compression method and wer...

The aim of this study was to develop methods for the design of hydroxypropyl methylcellulose (HPMC) tablets with specified drug profiles. This was achieved by the use of a mathematical model developed to predict the release kinetics of water-soluble drugs from HPMC matrices. The required model parameters were determined experimentally for propranolol HCl and chlorpheniramine maleate in 0. 1 N H...

propranolol, a prototypical b-adrenergic receptor antagonist and atenolol, a cardio-selective b-antagonist are widely used in therapeutic regimens for treatment of hypertensive patients. in iran, several pharmaceutical manufacturers formulate these two b-blockers. as the formulation of a dosage form is essential for the patient's safety and drug efficacy, in this study we aimed to evaluate...

hemangioma is the most common benign cutaneous vascular tumor in infants and children. the hemangioma incidence in the neonates is 2% to 3% that increases to 10% in those younger than one year of age. before introduction of propranolol in 2008, different medications such as systemic corticosteroids and vincristine, with different side effects, were used for years. since then, over 200 studies c...

conclusions our results demonstrated the promising prophylactic and therapeutic effects of propranolol against t. gondii infection. propranolol also increases the efficacy of pyrimethamine in combination therapies. results in the pre-treatment group, results showed that propranolol at 2 and 3 mg/kg combined with pyrimethamine was more effective in inhibiting growth of tachyzoites (86% and 98%, ...

introduction: previous studies have demonstrated that the &beta-adrenergic; receptor antagonist propranolol impairs fear memory reconsolidation in experimental animals. there are experimental parameters such as the age and the strength of memory that can interact with pharmacological manipulations of memory reconsolidation. in this study, we investigated the ability of the age and the strength ...

introduction: cytokines are a large group of proteins play a key role in inflammation. down-regulation of pro-inflammatory cytokines has beneficial effect on heart function. propranolol, as a non selective beta-adrenergic blocker, has been extensively used for treatment of many cardiovascular problems such as arrhythmias and heart malfunction. in addition anti-inflammatory effects of propranolo...