نتایج جستجو برای: prop1 gene
تعداد نتایج: 1141423 فیلتر نتایج به سال:
While the biological roles of canonical Wnt/beta-catenin signaling in development and disease are well documented, understanding the molecular logic underlying the functionally distinct nuclear transcriptional programs mediating the diverse functions of beta-catenin remains a major challenge. Here, we report an unexpected strategy for beta-catenin-dependent regulation of cell-lineage determinat...
BACKGROUND The adult endocrine pituitary is known to host several hormone-producing cells regulating major physiological processes during life. Some candidates to progenitor/stem cells have been proposed. However, not much is known about pituitary cell renewal throughout life and its homeostatic regulation during specific physiological changes, such as puberty or pregnancy, or in pathological c...
We describe a systems biology approach for the genetic dissection of complex traits based on applying gene network theory to the results from genome-wide associations. The associations of single-nucleotide polymorphisms (SNP) that were individually associated with a primary phenotype of interest, age at puberty in our study, were explored across 22 related traits. Genomic regions were surveyed ...
ژن prop1 بر روی کروموزوم 5 قرار گرفته و دارای 3 اگزون و 2 اینترون است. این ژن در غده هیپوفیز انسان و حیوانات اهلی از جمله گوسفند و بز باعث سنتز پروتئینی با 226 اسید آمینه می شود که تنظیم کننده بیان هورمون رشد، پرولاکتین و تیروتروپین است. هدف از این مطالعه بررسی چند شکلی اگزون 2 ژن prop1در نژادهای گوسفند لری بختیاری، زل و آمیخته زل-آتابای بود. در این تحقیق از 280 راس گوسفند شامل: 90 راس گوسفند ز...
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