gastric cancer (gc) is the second most common cancer in the world and a leading cause of cancer-related mortality. methylation of promoter cpg islands (cgis) belonging to tumor suppressor genes causes transcriptional silencing of their corresponding genes leading to carcinogenesis and other disorders. adenomatous polyposis coli (apc) a tumor suppressor gene is inactivated by methylation of prom...

congenital factor xiii deficiency is a very rare bleeding disorder, but because of the high rate of consanguineous marriages, it is common in sistan and baluchestan province of iran. the discovery of promoter hypermethylation of numerous mirnas in human diseases has demonstrated an epigenetic mechanism for aberrant mirna expression. the present study has analyzed methylation and expression stat...

background ovarian cancer is the most common fatal gynecologic malignancy in women. the brca2 gene has a role in regulation of cell cycle during proliferation, differentiation and dna repair. changes in the methylation of brca2 may be an effective mechanism for ovarian cancer. objectives the aim of the present study was to evaluate the association between ovarian cancer and methylation status o...

objective: runt-related transcription factor 2 (runx2) and osterix (osx) as two specific osteoblast transcription factors and distal-less homeobox 5 (dlx5) as a non-specific one are of paramount importance in regulating osteoblast related genes including osteocalcin, bone sialoprotein (bsp), osteopontin and collagen type iα1. the present study sets out to investigate whether epigenetic regulati...

Inorganic arsenicals are worldwide environmental contaminants that affect molecular characteristics in biological systems and lead to genomic and epigenomic instability as well as epithelial mesenchymal transition (EMT). In this study, we aimed to investigate whether low levels of sodium arsenite (iAsIII) can influence EMT and genomic instability through microsatellite analysis. We have also de...

objective: autism is a neurodevelopmental disorder characterized by difficulty in verbal and non-verbal communication, impaired social interaction, and restricted and repetitive behavior. it has been recently introduced as a multigenic disorder with significant epigenetic effects on its pathology. recently, epigenetic silencing of retinoic acid receptorrelated orphan receptor alpha (rorα) gene ...

objective: breast cancer is the most common cancer in iranian women. breast tumors are classified based on the estrogen receptor alpha (erα) expression status into er negative and er positive tumors. er negative tumors tend to have worse prognosis and less likely to respond to endocrine therapy. aberrant methylation of gene promoter is one of the mechanisms for gene silencing in breast tumors. ...

Background: VHL (von Hippel-Lindau), Runx-3 (Runt-related transcription factor 3), E-cadherin (Epithelial cadherin), P15 (INK4a, cyclin dependent kinase inhibitor), and P16 (INK4b) genes are essential in hematopoiesis. The aim of this study was to explore the correlation between gene expression and promoter methylation in CD34+ stem cells before and after differentiation to erythroid lineage. ...