Classically, the release of glutamate in response to a presynaptic action potential causes a brief increase in postsynaptic excitability. Previous reports indicate that at some central synapses, a single action potential can elicit multiple, asynchronous release events. This raises the possibility that the temporal dynamics of neurotransmitter release may determine the duration of altered posts...

chitosan with excellent biodegradable and biocompatible characteristics has received attention as an oral drug delivery vehicle for controlled-release formulations. in this study an enteric-coated capsule containing theophylline-chitosan beads based on 23 factorial designs was prepared as a colon drug delivery system. the theophylline-chitosan gel beads were formulated by adding the drug-contai...

Balancing the risks of prolonged gestation against those of induced labour is difficult. Risks to the fetus increase slightly after 42 weeks' gestation but women having labour induced are more likely to have instrumental deliveries or babies with low Apgar scores. Since many women are now expressing a preference for minimal interference in childbirth the most acceptable management of post-term ...

trial of the effects of prolonged-release melatonin, temazepam and zolpidem on slow-wave activity during sleep in healthy people. J Psychopharmacol. Abstract Current pharmacological treatments for insomnia include benzodiazepine and non-benzodiazepine hypnotics targeting GABA A receptors, as well as agonists of the melatonin receptors MT1 and MT2. Melatonin, temazepam and zolpidem are thought t...

Neuronal dense-core vesicles (DCVs) contain diverse cargo crucial for brain development and function, but the mechanisms that control their release are largely unknown. We quantified activity-dependent DCV release in hippocampal neurons at single vesicle resolution. DCVs fused preferentially at synaptic terminals. DCVs also fused at extrasynaptic sites but only after prolonged stimulation. In m...

INTRODUCTION Discussions among Norwegian obstetricians on how to handle prolonged pregnancies have been ongoing throughout the past decade. In 2011, the Norwegian Directorate of Health recommended a specialist care consultation one week after the estimated date of delivery, implying prompt induction of labour in women at risk. The aim of this study was to compare an expectant management with a ...

the aim of this study was preparation and evaluation of ciprofloxacin-containing minitablets for ocular use, in an attempt to obtain prolonged and controlled drug release to the anterior eye segment. following initial studies on ciprofloxacin powder, it was formulated into ocular minitablets. for this purpose, ciprofloxacin along with various amounts of different sustained release cellulose der...

Abstract Levetiracetam as an Anti-epileptic drug with exclusive mechanism of action is accepted by the USA Food and Drug Administration as an adjunctive therapy in treating epilepsy in young adults. The purpose of this project is the design and formulation of prolonged release of levetiracetam using two types of retarding agent such as Hydroxyl Propyl Methylcellulose (HPMC K4...

Hydrogels with three-dimensional network structure, hydrophilic, and insoluble in water which are ideal carrier materials for intelligent drug delivery systems. Intelligent hydrogel has become a research frontier hotspot because of its intelligence, high efficiency, safety, convenience controlled prolonged release. It broad application prospect the medicine biomedicine fields can lead into new ...

the objective of the present study was to design an oral controlled drug delivery system for sparingly soluble diclofenac sodium (dcl) using guar gum as triple-layer matrix tablets. matrix tablet granules containing 30% (d1), 40% (d2) or 50% (d3) of guar gum were prepared by the conventional wet granulation technique. matrix tablets of diclofenac sodium were prepared by compressing three layers...