Die praxisrelevante Performanzanalyse großer, nebenläufiger Systeme ist unzureichend gelöst. Das Zusammenwirken von Modulen, und damit die teilweise Ursache von Performanzproblemen kann nur sehr schwer erkannt werden. Durch künstliche Verlängerungen der Laufzeit einzelner Module können Hinweise auf Zusammenhänge im System erschlossen werden. Das System wird dazu unter einer statistischen Perspe...

The notion of a prolongation of an algebraic variety is developed in an abstract setting that generalises the difference and (Hasse) differential contexts. An interpolating map that compares these prolongation spaces with algebraic jet spaces is introduced and studied.

We investigate segment prolongation as a means of disfluent hesitation in spontaneous German speech. We describe phonetic and structural features of disfluent prolongation and compare it to data of other languages and to non-disfluent prolongations.

This paper presents a corpus-based study on prolongations in spontaneous Mandarin. Prolongations are mainly produced for hesitation, but also for emphasizing a discourse focus and signalling an explicit feedback. 786 prolongation occurrences are investigated in terms of the position, the part of speech and the segment and tone types. Prolongations are often found in word-final, phrase-final and...

The drug-induced QT prolongation predisposes to development of torsades de pointes (TdP) ventricular tachycardia and sudden death. The association between specific drug and development of TdP is difficult to document, therefore, QT prolongation is considered as a surrogate marker of the proarrhythmia risk. Most of the drugs prolong QT interval usually by blocking the potassium IKr current or al...

We introduce a novel technique for constructing higher-order variational integrators for Hamiltonian systems of ODEs. In particular, we are concerned with generating globally smooth approximations to solutions of a Hamiltonian system. Our construction of the discrete Lagrangian adopts Hermite interpolation polynomials and the Euler–Maclaurin quadrature formula, and involves applying collocation...

There have been only two previous reports of paroxetine-induced corrected QT (QTc) prolongation on electrocardiogram (ECG). Here, we report a 43-year-old woman with QTc prolongation (476 ms). She had taken 50 mg of paroxetine for 17 days. Three days after discontinuation of paroxetine, QTc returned to within the normal limits (396 ms). Paroxetine blocks the human ether-a-go-go-related gene (HER...

OBJECTIVE The aim of this study was to examine whether or not levofloxacin has any relationship with QT prolongation in a real clinical setting by analyzing a clinical data warehouse of data collected from different hospital information systems. METHODS Electronic prescription data and medical charts from 3 different hospitals spanning the past 9 years were reviewed, and a clinical data wareh...

It has been shown previously in a number of systems that after an extended block of activity, synaptic strength is increased. We found that an extended block of synaptic activity at the mouse neuromuscular junction, using a tetrodotoxin cuff in vivo, increased synaptic strength by prolonging the evoked endplate current (EPC) decay. Prolongation of EPC decay was accompanied by only modest prolon...

background: although various anesthetic techniques can be used in different kinds of surgeries, spinal anesthesia has received considerable attention for the lower abdomen and lower extremities surgeries and cesarean section. this study aimed at comparing the effect of adding epinephrine 1:1000 and 1:10000 to lidocaine and fentanyl in spinal anesthesia on the prolongation of paralysis, analgesi...