purpose: to evaluate the success rate of vitrectomy in giant retinal tears (gtr) and factors influencing it. methods: in an interventional case series, hospital records of 68 eyes of 63 patients operated for grt were reviewed. standard three port vitrectomy plus placement of an encircling band, retinopexy, and internal tamponade was performed for all eyes. possible influencing factors including...

Histiocytoses describe a diverse group of proliferative disorders involving dentritic cells and macrophages. They include a spectrum of diseases including a reactive inflammatory accumulation of cells, pathologic immune activation, or neoplastic clonal proliferation. Advanced molecular technologies are resulting in new breakthroughs in understanding the pathophysiology of histiocytic disorders ...

Eight eyes exhibited massive proliferation of lens epithelial remnants following Nd-YAG posterior capsulotomy. All eyes had pre-existing retinal pathology. Six had undergone vitrectomy (four for proliferative diabetic retinopathy) before extracapsular cataract extraction with posterior chamber intraocular lens implantation. The other two eyes had familial exudative vitreoretinopathy or retinopa...

Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells in culture, is expressed in vivo in a variety of inflammatory conditions associated with cell proliferation, including atherosclerosis, wound repair, pulmonary fibrosis, and glomerulonephritis. However, it is not known if PDGF mediates the fibroproliferative responses that characterize these inflammatory disorders. We...

Patients with diabetes are at great risk to suffer many musculoskeletal disorders, such as tendinopathy, tendon rupture and impaired tendon healing. However, the pathogenesis of these tendon disorders still remains unclear. In this study, we aimed to investigate the effects of high glucose on cell proliferation, cell apoptosis and tendon-related markers expression of tendon-derived stem cells (...

Macrophages have long been known to play a major role in the pathogenesis of proliferative vitreoretinal disorders. Using the monoclonal antibodies EBM11 (pan macrophage), 27E10 (early inflammatory stage marker), and RM3/1 (healing phase marker), different subpopulations of macrophages were differentiated in surgically removed membranes from patients with macular pucker (n = 6), proliferative v...

Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Large granular lymphocytes (LGLs) are medium-to-large cells, of either Tor natural killer (NK)-cell lineage, characterized by eccentric nuclei, condensed chromatin, and abundant pale cytoplasm containing coarse azurophilic granules (1, 2). Proliferative conditions of Tand NKLGLs represent a complex spectrum of different clini...

Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by clonal proliferative hematopoiesis with increased blood cell count. Clonal expansion mechanisms in MPN and related disorders such as myelodysplastic syndromes (MDS) remain to be elucidated. Although mutations in the JAK2...