BACKGROUND Mitral valve prolapse (MVP) is usually benign, although serious complications may occur. It remains unclear whether the region of prolapsed mitral leaflets might affect prognosis. The aim of this study was to investigate lesional differences of clinical courses of MVP. METHODS AND RESULTS We retrospectively investigated 128 MVP patients who had been followed up for for a mean of 56...

BACKGROUND In patients with mitral valve prolapse, nonprolapsed leaflets are often apically tented. We hypothesized that secondary left ventricular dilatation attributed to primary mitral regurgitation (MR) causes papillary muscle (PM) displacement, resulting in this leaflet tenting/tethering, and that secondary tethering further exacerbates malcoaptation and contributes to MR severity. METHO...

BaIlon mitral valvuloplasty and closed mitral valve conunissurotomy were performed in 450 and 127 patients, respectively. Also, 254 patients with severe mitral stenosis were enrolled in a prospective randomized trial comparing the two procedures. Immediately after balloon mitral valvuloplasty, mean left atrial pressure was 11.38±3.54 mmHg, transmitral valve gradient was 1.8±2 mmHg, and mit...

Marfan's syndrome (MFS) is an inherited autosomal dominant disorder of connective tissue with mutation on the fibrillin-1 gene encoding for fibrillin. This frequently involves the cardiovascular system with prevalence is 1:5000-10,000. The clinical major criteria involve the skeletal and ocular apparatus and the cardiovascular and central nervous system. In Marfan's syndrome mitral valve prolap...

CHEST, 78: 1, JULY, 1980 3 Barlow JB, Bosman CK, Pocock WA, et al. Late systolic murmurs and no-ejection (“mid-late”) systolic clicks: an analysis of 90 patients. Br Heart J 1968; 30:203-18. 4 Jeresaty RM. Mitral ballooning: a possible mechanism of mitral insufficiency in diseases associated with reduced end-systolic volume of the left ventricle. Chest 1971; 60: 114-5. S Winkle BA, Lopes MC, Go...

We read with interest the report by Marlow et al on an infant with Marfan's syndrome and mitral valve dysfunction who died after acute illness with gross cardiac failure.' The authors stated that 'disease affecting the mitral valve is usually more benign than that of the aortic valve ....' This statement, however, may not be applicable to infants and young children with Marfan's syndrome. We ha...

bailon mitral valvuloplasty and closed mitral valve conunissurotomy were performed in 450 and 127 patients, respectively. also, 254 patients with severe mitral stenosis were enrolled in a prospective randomized trial comparing the two procedures. immediately after balloon mitral valvuloplasty, mean left atrial pressure was 11.38±3.54 mmhg, transmitral valve gradient was 1.8±2 mmhg, and mitral v...

Introduction: Computational modeling is one of the best non-invasive approaches to predicting functional behavior mitral valve (MV) in health and disease. Mitral prolapse (MVP) due partial or complete chordae tendineae rapture most common valvular disease results regurgitation (MR). Methods: In this study, Image-based fluid-structure interaction (FSI) models human MV are developed normal physio...