Glucocorticoids are drugs of choice for treatment of laryngotracheitis (croup). They may be administered orally as tablets or juice, locally as inhalation or rectally as suppository or capsule. If doctors decide to use a rectal administration for practical reasons, it is obvious from a pharmacokinetic and pharmacodynamic point of view that prednisolone capsules have an earlier and stronger anti...

BACKGROUND Theophylline has been widely used to treat asthma, but recent studies have revealed that the possible risks for seizure may result in the revision of the therapeutic guidelines. METHODS An 8-month-old boy who had been treated with oral sustained-release theophylline and additional aminophylline suppository was hospitalized. A combination of diazepam, lidocaine and thiopental was re...

this study investigated efficacy and side effects of morphine suppository for pain management after the first elective caesarean delivery in comparison to diclofenac suppository. one hundred women aged 18-40 with term pregnancies undergoing elective caesarean section for the first time participated in this prospective project. exclusion criteria included drug sensitivity, fetal malformations or...

Spring-calving, crossbred (1/4 to 3/8 Brahman) primiparous (n = 56) and multiparous (n = 102) beef cows were used to evaluate the effects of progesterone, delivered via a controlled internal drug-releasing (CIDR) device, and prostaglandin F(2alpha) (PGF(2alpha)) on estrous behavior, synchronization rate, initiation of estrous cycles, and pregnancy rate during a 2-yr period. To determine luteal ...

Paracetamol is commercially available in oral and rectal dosage forms for geriatric and pediatric patients. Limitation of oral drug delivery for pediatric patient is inconvenience to swallow the tablet, capsule and oral suspension; in such case suppositories are effective and often used. To achieve successful delivery of drug locally as well as systematically, rectal route has proved its potent...

The objective was to evaluate whether addition of EAZI-BREED CIDR Cattle Inserts (CIDR) to the Ovsynch program increases first service pregnancy rate (PR) in lactating dairy cows. The study was conducted in 5 dairies in Central Mexico. Cows were inseminated from June through September, 2001. Within trial site and within parity, cows were assigned to either an Ovsynch (n=255) or an Ovsynch-CIDR ...

AIM To determine the effects of hyoscine-N-butyl bromide (HBB) rectal suppository on labor progress in primigravid women. METHODS A randomized double-blind placebo-controlled clinical trial was carried out on 130 primigravid women admitted for spontaneous labor. The women were recruited based on the inclusion and exclusion criteria and randomized into the experimental (n=65) and control group...

BACKGROUND The methods of evaluating endoscopic mucosal findings and the definition of mucosal healing in inflammatory bowel disease have not been standardized. AIM To examine a third-party central review of colonic mucosal evaluations. METHODS A double-blind, placebo-controlled, parallel-group trial was performed for 4weeks, which involved continuous administration of a 1-g mesalazine supp...