Objectives: To assess and compare the maintenance of tocolysis in preterm labor by using vaginal intramuscular progesterone. Study design: Randomized controlled trial. Settings study duration: Department Obstetrics & Gynecology, Civil Hospital, Bahawalpur between 12th March 2019 11th September Materials Methods: A total 96 women ranging from 18 40 years age presented with threatened labour,...

ectopic pregnancy (ep) and miscarriage are important differential diagnosis of first trimester vaginal bleeding. in first trimester, serum progesterone value can be 5-20 ng/ml in ep and miscarriage. since delay in diagnosis of ep could have high mortality and morbidity, the aim of this study was comparison of serum progesterone value in ep and miscarriage in order to differentiate these conditi...

background: the preparation of endometrium for embryo reception and implantation are controlled by ovarian hormones. these hormones have distinct cyclical changes during estrus cycle. objective: the aim of this study was to evaluate the changes in morphology and morphometrical indices of endometrium by daily injections of estrogen and progesterone in ovariectomized mouse. materials and methods:...

Progesterone is essential for endometrial receptivity and successful establishment of pregnancy. Either an insufficient progesterone concentration or an insufficient response to progesterone, therefore can lead to infertility and pregnancy loss. Assessment of the role that either progesterone insufficiency or inadequate progesterone response plays in human reproductive failure has been difficul...

In the kidney, progesterone is inactivated to 20alpha-dihydro-progesterone (20alpha-DH-progesterone) to protect the mineralocorticoid receptor from progesterone excess. In an attempt to clone the enzyme with 20alpha-hydroxysteroid activity using expression cloning in CHOP cells and a human kidney expression library, serendipitously cDNA encoding CYP27A1 was isolated. Overexpression of CYP27A1 i...

background: luteal phase support is mandatory in art (assisted reproductive technologies) for optimizing outcome, so the luteal phase is supported with either progesterone, addition of estradiol to progesterone, hcg or gonadotropin releasing hormone (gnrh) agonists. supplementation of luteal phase with progesterone is prescribed for women undergoing routine ivf treatment. objective: to compare ...

Objective: Compare the pharmacokinetics of vaginal progesterone gel (Crinone 8%, 90 mg) with that of oral progesterone (Prometrium, 100 mg). Design: Open-label, randomized, parallel-group protocol. Setting: Outpatient clinic. Patient(s): Twelve healthy postmenopausal women. Intervention(s): Six subjects each were randomized to receive progesterone, which was administered either as 90 mg of prog...