Problem Solving Environment (PSE) provides computational facilities to the activities carried out by scientists. The development of this kind of applications is a real challenge for the scientific community. At present, complex software systems, to provide computing services at different levels, are built as the integration of remote and distributed software and hardware components. The key to ...

To enhance engineering insight, reduce development costs and improve product quality, design studies are increasingly using sophisticated analysis packages together with optimisation tools. This combined approach requires a high level of systems integration and the ability to exploit clusters of networked workstations to achieve efficient and re-usable design systems. What is a PSE " A PSE is a...

One of the most important contributions Japanese researchers is proposition superstructure concept. Umeda and coworkers proposed in 1972 a system structure for reaction-separation process which split ratios determine connecting flows. Later, this concept changed to parameter and, finally, superstructure. Since 1980, superstructure-based optimization has been very active field Process Systems En...

In this paper we show how a Problem Solving Environment (PSE) can be used to manage and steer numerical optimisation of a challenging problem from mechanical engineering running in parallel on a remote Grid resource. The industrial code used by Shell Global Solutions in their lubrication work is transformed from a serial code through an interactive PSE providing multivariate visualisations to a...

— For nanotechnology, the semiconductor device is scaled down dramatically with additional strain engineering for device enhancement, the overall device characteristic is no longer dominated by the device size but also circuit layout. The higher order layout effects, such as well proximity effect (WPE), oxide spacing effect (OSE) and poly spacing effect (PSE), play an important role for the dev...

In this paper, we introduce a new framework called PSE Park for constructing a Problem Solving Environment (PSE); it enables us to construct PSEs easily. PSE Park outputs PSEs depending on user’s demand/input. In this sense, PSE Park is a kind of PSE for PSE, and helps users to construct PSEs. PSE Park consists of four engines: PIPE server, core, registration engine, and console. A PSE designed...

The in situ regeneration of reduced nicotinamide cofactors (NAD(P)H) is necessary for practical synthesis of many important chemicals. Here, we report the engineering of a highly stable and active mutant phosphite dehydrogenase (12x-A176R PTDH) from Pseudomonas stutzeri and evaluation of its potential as an effective NADPH regeneration system in an enzyme membrane reactor. Two practically impor...