Tumor-mobilized bone marrow–derived CD11bþ myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here, we show that CD11bþ myelomonocytic cells develop proangiogenic properties during their differentiation from CD34þ hematopoietic progenitors and that placenta growth factor (PlGF) is critical in promoting this education....

Tumor-mobilized bone marrow-derived CD11b(+) myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here, we show that CD11b(+) myelomonocytic cells develop proangiogenic properties during their differentiation from CD34(+) hematopoietic progenitors and that placenta growth factor (PlGF) is critical in promoting this educ...

OBJECTIVES The pathogenesis of the higher occurrence of peptic ulcer disease in cirrhotic patients is complex. Platelets can stimulate angiogenesis and promote gastric ulcer healing. We compared the expressions of proangiogenic growth factors and their receptors in the gastric ulcer margin between cirrhotic patients with thrombocytopenia and those of non-cirrhotic patients to elucidate possible...

Colorectal cancer (CRC) is a common solid tumor and it is a leading cause of cancer related death especially in developed countries (Center et al., 2009). About 500,000 deaths are reported per year worldwide due to CRC. Environmental factors, dietary habits, inflammatory bowel disease, age, male sex, and hereditary syndromes are a higher risk in the development of this disease (Chu, 2012). Impr...