نتایج جستجو برای: primary central nervous system lymphoma pcnsl
تعداد نتایج: 3162801 فیلتر نتایج به سال:
Context Primary central nervous system lymphoma (PCNSL) is a variant of extranodal lymphoma, accounting for 4% of primary central nervous system tumors. PCNSL was more common in immunocompetent individuals. International Extranodal Lymphoma Study Group (IELSG) scoring was used for prognostication. High-dose methotrexate regimens along with radiotherapy improved outcomes in PCNSL. Aims The aim...
A 72-year-old man was admitted with left homonymous hemianopsia and hemiparesis. Magnetic resonance imaging revealed a heterogeneously enhanced lesion in the right parietal lobe. A brain biopsy showed acute demyelination without malignancy, which led to a diagnosis of tumefactive multiple sclerosis (MS). The patient received corticosteroid therapy and experienced clinical and radiological impro...
Purpose: Our objective was to identify the genetic changes involved in primary central nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance. Experimental Design: We investigated a series of 29 newly diagnosed, HIV-negative, PCNSL patients usinghigh-resolution single-nucleotide polymorphism (SNP) arrays (n1⁄429) andwhole-exome sequencing (n1⁄4 4) approaches. Recurren...
Primary dural lymphoma (PDL) is a subtype of primary central nervous system (CNS) (PCNSL) with only an extra-axial location. It accounts for less than 1% all CNS lymphomas. PDL sporadic tumor, and in the preoperative period, because imaging characteristics, it usually mimicking meningioma. Usually, low-grade B-cell relatively good response to surgical resection or without radiotherapy. Here we ...
SLIT2 constitutes a known tumour suppressor gene, which has not yet been implicated in the pathogenesis of primary central nervous system lymphoma (PCNSL). Performing exome sequencing on paired blood and DNA samples from six treatment-naïve PCNSL patients, we identified novel variants (p.N63S, p.T590M, p.T732S) that were associated with shorter progression-free survival our cohort overall large...
Primary central nervous system lymphoma (PCNSL) is a rare disorder that, in 95% of cases, represents diffuse large B-cell lymphoma. As such, making an accurate diagnosis is important. At present, stereotactic-guided biopsy is a recognized method of choice for tissue analysis. However, the diagnostic work-up for high-risk patients is determined by their performance status. Here, we report a case...
PURPOSE The prospect for advances in the treatment of patients with primary central nervous system lymphoma (PCNSL) is likely dependent on the systematic evaluation of its pathobiology. Animal models of PCNSL are needed to facilitate the analysis of its molecular pathogenesis and for the efficient evaluation of novel therapeutics. EXPERIMENTAL DESIGN We characterized the molecular pathology o...
Primary central nervous system lymphoma (PCNSL) is a rare but often rapidly fatal form of non-Hodgkin B-cell lymphoma that arises within the central nervous system (CNS) and has a low propensity to metastasize. We performed immunohistochemistry on formalin-fixed, paraffin-embedded brain biopsy specimens from 24 patients with PCNSL to investigate the expression of B cell-attracting chemokine 1 (...
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