It is well known that more than 50% of the patients with osteosarcoma affected pulmonary metastasis at the time of diagnosis of the primary lesion although such a dormant micrometastasis is often asymptomatic and clinically undetectable until relapse. There are several clinical evidences showing that some of these patients relapse of pulmonary metastasis within months after the removal of the p...

Osteosarcoma refers to a bone tumor and the term was introduced by John Abernathy in 1804 referring fleshy growth [1]. In 2009, Ottaviane G. et al reported that osteosarcoma is an aggressive malignancy arises from primitive transformed cells of mesenchymal origin produces malignant osteoid, which are most common representation primary cancer [2,3].

Mammary sarcomas are very uncommon and make up less than 1% of all primary breast malignancies.Primary osteosarcoma of the breast is extremely rare and represents 12.5% of mammary sarcomas. A secondary lesion from a primary osteosarcoma of the bone should be considered in the differential diagnosis. In addition, the absence of a direct connection between the tumour and the underlying skeleton i...

PURPOSE Osteosarcoma is the most common cancer of bone occurring mostly in teenagers. Despite rapid advances in our knowledge of the genetics and cell biology of osteosarcoma, significant improvements in patient survival have not been observed. The identification of effective therapeutics has been largely empirically based. The identification of new therapies and therapeutic targets are urgentl...

Abstract Background Although osteosarcoma remains the most common primary malignant neoplasm in bone pediatric age group, involvement of foot is extremely rare. Case presentation Our case demonstrates what appeared to be a cyst calcaneus at an outside institution after injury ankle. The patient was sent our for further workup where Computed Tomography scan revealed permeative lytic lesion with ...

Microenvironment at the metastatic locus usually differs greatly from that present in the site of primary tumor formation and it has a significant impact on the fate of the extravasated cancer cells. We compared gene expression signatures of primary tumors and lung metastatic tumors, and identified Thrombospondin-1 (TSP1) as highly up-regulated in the lung metastatic tumors. Immunohistochemical...

To the Editor: We have read with great interest the article by Gu and coworkers reporting the coxsackievirus and adenovirus receptor (CAR) status on primary musculoskeletal tumors (1). We are particularly interested in their findings on osteosarcomas because we are developing gene therapy strategies for this cancer. CAR is the high-affinity viral receptor for most human adenovirus serotypes inc...