We examined the effects of cholinergic deficiency on prepulse inhibition (PPI) of the acoustic startle. Rats treated with a choline-free diet that contained the false cholinergic precursor N-aminodeanol showed great deficit in PPI. This deficit does not appear to be secondary to an increase of stereotyped behaviors. Startle threshold was also greatly reduced, as these rats startled to the 70-dB...

The acoustic startle response (ASR) and its modulation by non-startling prepulses, presented shortly before the startle-eliciting stimulus, is a broadly applied test paradigm to determine changes in neural processing related to auditory or psychiatric disorders. Modulation by a gap in background noise as a prepulse is especially used for tinnitus assessment. However, the timing and frequency-re...

The effectiveness of different types of auditory prepulses in eliciting skin conductance orienting and in producing prepulse inhibition (PPI) of the acoustic startle eyeblink was studied in two experiments. A discrete white noise prepulse produced greater PPI than either a continuous white noise, a discrete tone, or a continuous tone. The discrete white noise advantage was not due to similarity...

Dopaminergic induced changes in Mauthner-cell excitability disrupts prepulse inhibition 1 in the startle circuit of goldfish. 2 3 Violeta Medan and Thomas Preuss 4 5 Department of Psychology, Hunter College, City University of New York 6 695 Park Avenue, New York, NY 10065 7 8 Running head: dopaminergic disruption of prepulse inhibition 9 10 Corresponding author: Thomas Preuss, [email protected]...