20 Isoflurane is a representative inhalant anesthesia used in laboratory animals. 21 However, isoflurane mediates respiratory depression and adverse clinical reactions 22 during induction. In the present study, we established a novel balanced anesthesia 23 method in mice that combined isoflurane anesthesia with midazolam and butorphanol 24 (MB). 25 Thirty-four male C57BL/6J mice received either...

Although oral clonidine premedication is known to reduce the hemodynamic response under general anesthesia, effects of the hemodynamic response during sedated fiberoptic nasal intubation have not yet been examined. Our aim was to compare the effects of clonidine premedication on hemodynamic responses with those of atropine and hydroxyzine premedication during sedated fiberoptic nasal intubation...

how to cite this article: derakhshanfar h, modanlookordi m, amini a, shahrami a. a comparative study of the sedative effect of oral midazolam and oral promethazine medication in lumbar puncture. iran j child neurol. 2013 spring;7(2):11-16.   objective lumbar puncture (lp) essentially is a painful and stressful procedure that indicated for diagnosis and therapeutic purposes. one way to reduce th...

We studied the effects of temazepam premedication and induction of anaesthesia with thiopentone or propofol on the heart rate power spectrum in 47 patients undergoing elective minor surgery. Eighteen patients received temazepam 20 mg orally as premedication. There was a significant reduction in high frequency power and total power, and an increase in the ratio of low to high frequency power aft...

Aim: To evaluate the effects of Dexmedetomidine to reduce the intra ocular pressure and sedation in day care cataract surgeries. Materials and methods: This study was conducted in 50 patients of either sex, belonging to 40 – 60 years of age, ASA grade I and II admitted for cataract surgeries. Patients were randomized into two groups of 25 each. Group D received 1 mcg/mg of Dexmedetomidine as IM...

BACKGROUND Premedication with beta-2 agonists (e.g. salbutamol) is effective in preventing increases in total respiratory resistance and in decreasing the incidence of perioperative bronchospasm in asthmatic children. Because children with recent respiratory tract infection (RTI) exhibit bronchial hyperreactivity similar to that observed in asthmatic children, the use of salbutamol in children ...

Background: The majority of patients admitted to the hospital for elective surgery experience anxiety preoperatively which can adversely influence surgical procedure as well patient’s recovery. Reduction and fear at preoperative period in is essential preparation. Benzodiazepines are most commonly used drugs this purpose. Materials Methods: study was carried out on a series 60 consecutivepatien...

A placebo controlled randomized double blind study was designed to assess the suitability of oral Midazolam as a premedication in day care surgery in adult Pakistani patients. Fifty ASA I and II patients aged between 20-60 years received either Midazolam 7.5 mg or a placebo approximately one hour prior to surgery. Midazolam 7.5 mg produced significant anxiolysis and sedation (p < 0.001) in comp...

BACKGROUND The role of anxiolytic premedication remains unclear and significant postoperative side-effects may result from routine use. METHODS In this double-blinded study, 100 infertile patients were randomized on the day of ultrasound-guided oocyte retrieval (TUGOR) by a computer-generated randomization list in sealed envelopes to receive either (i) 50 mg pethidine and 25 mg promethazine (...

Isoflurane is a representative inhalant anesthesia used in laboratory animals. However, isoflurane mediates respiratory depression and adverse clinical reactions during induction. In the present study, we established a novel balanced anesthesia method in mice that combined isoflurane anesthesia with midazolam and butorphanol (MB). Thirty-four male C57BL/6J mice received either isoflurane alone ...