Resin Transfer Molding (RTM) is a composite manufacturing process. A preformed fiber is placed in a closed mold and a viscous resin is injected into the mold. In this paper, a model is developed to predict the flow pattern, extent of reaction and temperature change during filling and curing in a thin rectangular mold. A numerical simulation is presented to predict the free surface and its inter...

Resin Transfer Molding (RTM) is a composite manufacturing process. A preformed fiber is placed in a closed mold and a viscous resin is injected into the mold. In this paper, a model is developed to predict the flow pattern, extent of reaction and temperature change during filling and curing in a thin rectangular mold. A numerical simulation is presented to predict the free surface and...

Metabolites in safety testing have gained a lot of attention recently. Regulatory agencies have suggested that the kinetics of preformed and in vivo-formed metabolites are comparable. This subject has been a topic of debate. We have compared the kinetics of in vivo-formed with preformed metabolites. trans-3,5,4'-Trihydroxystilbene [trans-resveratrol (RES)] and its two major metabolites, resvera...

Hsp104, a hexameric AAA+ ATPase found in yeast, transduces energy from cycles of ATP binding and hydrolysis to resolve disordered protein aggregates and cross-b amyloid conformers. These disaggregation activities are often co-ordinated by the Hsp70 chaperone system and confer considerable selective advantages. First, renaturation of aggregated conformers by Hsp104 is critical for yeast survival...

In type-2 diabetes (T2D) and Parkinson's disease (PD), polypeptide assembly into amyloid fibers plays central roles: in PD, α-synuclein (aS) forms amyloids and in T2D, amylin [islet amyloid polypeptide (IAPP)] forms amyloids. Using a combination of biophysical methods in vitro we have investigated whether aS, IAPP, and unprocessed IAPP, pro-IAPP, polypeptides can cross-react. Whereas IAPP forms...

Alzheimer disease is characterized by the presence of increased levels of the β-amyloid peptide (Aβ) in the brain parenchyma and cerebral blood vessels. This accumulated Aβ can bind to fibrin(ogen) and render fibrin clots more resistant to degradation. Here, we demonstrate that Aβ(42) specifically binds to fibrin and induces a tighter fibrin network characterized by thinner fibers and increased...

Alzheimer disease is characterized by the presence of increased levels of the amyloid peptide (A ) in the brain parenchyma and cerebral blood vessels. This accumulated A can bind to fibrin(ogen) and render fibrin clots more resistant to degradation. Here, we demonstrate that A 42 specifically binds to fibrin and induces a tighter fibrin network characterized by thinner fibers and increased resi...