Differential Expression of TcR-CD3 Zeta as Evidence for Altered Immunoregulation in Preeclamptic vs. Normotensive Women Garrett K. Lam, MD, Paul W. Whitecar, MD, Susan Orton, PhD, Kim A. Boggess, MD, Douglas D. Taylor, PhD Objective: To exhibit and quantify the difference in modulation of CD3-zeta protein (an integral component of the T-cell receptor) in preeclamptic and normotensive women. Stu...

Aim: To evaluate the levels of C Reactive protein, an inflammatory marker in preeclamptic and normotensive pregnant women. Methods: It was a cross sectional analytical study. The participants included 60 cases with preeclampsia and 60 normotensive pregnant women, all in their third trimester. All the participants were in the age group of 20-40 years and a BMI of 18-25. HsCRP levels were measure...

background: leptin is a protein product of obesity gene and is synthesized mainly by adipose tissue. objective: the aim of this study was to determine maternal and neonatal serum leptin levels in term preeclamptic and normal pregnancies. materials and methods: this cross sectional study was performed on 37 preeclamptic and 40 normotensive term pregnant women without other disease. serum level o...

BACKGROUND: The aim of the present case control study was to evaluate the association between maternal periodontitis and preeclampsia. Objectives: To evaluate following periodontal parameters in women with preeclampsia & to compare them with non-preeclamptic women. 1. Bleeding on probing, 2 .Probing depth, 3. Clinical attachment level MATERIAL AND METHODS: Initially 310 women were included in t...

Uterine natural killer cells are important for uteroplacental development and pregnancy maintenance. Their role in pregnancy disorders, such as preeclampsia, is unknown. We reduced the number of natural killer cells by administering rabbit anti-asialo GM1 antiserum in an established rat preeclamptic model (female human angiotensinogen×male human renin) and evaluated the effects at the end of pr...

Preeclampsia is a serious pathologic complication during pregnancy, and its pathogenesis remains poorly understood. Recent studies have demonstrated that autoantibodies against angiotensin II type 1A receptor (AT1-AA) are present in women with preeclampsia. However, their role in the development of hypertension in preeclamptic patients has never been previously investigated. The present study w...

Formerly preeclamptic women are at risk for cardiovascular disease. Low plasma volume may reflect latent hypertension and potentially links preeclampsia with chronic cardiovascular disease. We hypothesized that low plasma volume in normotensive formerly preeclamptic women predisposes to hypertension. We longitudinally studied n=104 formerly preeclamptic women in whom plasma volume was measured ...

BACKGROUND Preeclampsia is the most common serious disorder during pregnancy and studies show several immune-related processes in its pathophysiology. The role of cytokines and their expression remains controversial in this field. One of the cytokines of interest in recent studies has been TNF-α, which has been shown to have a higher level in maternal plasma of preeclamptic women. OBJECTIVES ...

BACKGROUND Increased fetal DNA in maternal plasma/serum has been reported in pregnancies complicated by preeclampsia. We hypothesized that impaired clearance of fetal DNA might contribute, at least in part, to the above-mentioned phenomenon. METHODS We studied 7 preeclamptic and 10 control pregnant women. All had male fetuses. Serial blood samples were obtained from before delivery to 6 h pos...

Leptin has been measured in the fetal circulation and plasma leptin may also originate from a range of other fetal and placental tissues. The present study was designed to analyze leptin levels in women with preeclampsia and to assess its relationship with renal functions, gestational age and outcome of pregnancy. Twenty five normotensive pregnant women and 25 age and gestation matched preeclam...