BACKGROUND MicroRNAs (miRNAs) are short noncoding RNAs integral for regulating gene expression at the posttranscriptional level. However, experimental methods often fall short in finding miRNAs expressed at low levels or in specific tissues. While several computational methods have been developed for predicting the localization of mature miRNAs within the precursor transcript, the prediction ac...

MicroRNAs are regulated by gene alteration, transcription, and processing. Thus far, few studies have simultaneously assessed all 3 levels of regulation. Using real-time quantitative polymerase chain reaction (QPCR)-based arrays, we determined changes in gene copy number, pre-miRNA, and mature miRNA levels for the largest set of primary effusion lymphomas (PELs) to date. We detected PEL-specifi...

MicroRNAs are regulated by gene alteration, transcription, and processing. Thus far, few studies have simultaneously assessed all 3 levels of regulation. Using real-time quantitative polymerase chain reaction (QPCR)–based arrays, we determined changes in gene copy number, pre-miRNA, and mature miRNA levels for the largest set of primary effusion lymphomas (PELs) to date. We detected PELspecific...

OBJECTIVE To estimate the effect of partner change on risks of pre-eclampsia and giving birth to a small for gestational age infant. DESIGN Prospective population study. SETTING Sweden. PARTICIPANTS Women with their first and second successive singleton births in Sweden between 1990 and 2006 without pregestational diabetes and/or hypertension (n=446 459). OUTCOME MEASURES Preterm (<37 w...

It has been reported previously that infant faces elicit enhanced attentional allocation compared to adult faces in adult women, particularly when these faces are emotional and when the participants are mothers, as compared to non-mothers [1]. However, it remains unclear whether this increased salience of infant faces as compared to adult faces extends to children older than infant age, or whet...

Interpretation of measurements of visual performance in infants must be based on knowledge of the locus of highest sensitivity in the infant retina. While we know that adult contrast sensitivity and spatial resolution is highest at the fovea, recent anatomical data show that the infant fovea is relatively immature. We have studied that variation of contrast sensitivity across the visual field d...

In this work, we examine a context in which a conflict arises between two roles that infant-directed speech (IDS) plays: making language structure salient and modeling the adult form of a language. Vowel devoicing in fluent adult Japanese creates violations of the canonical Japanese consonant-vowel word structure pattern by systematically devoicing particular vowels, yielding surface consonant ...

based on rome iii criteria, functional disorders of gi are listed below:   infant regurgitation: -regurgitation two or more times per day for 3 or more weeks -no retching, hematemesis, aspiration, apnea, ftt, abnormal posturing infant rumination syndrome: -repetitive contraction of abdominal muscle -regurgitation of gastric content in to the mouth and reswallowed cyclic vomiting syndrome: -two ...

Quantitative real-time PCR (QPCR) has emerged as an accurate and valuable tool in profiling gene expression levels. One of its many advantages is a lower detection limit compared to other methods of gene expression profiling while using smaller amounts of input for each assay. Automated qPCR setup has improved this field by allowing for greater reproducibility. Its convenient and rapid setup al...

At birth the newborn infant is required to make an abrupt adjustment to a new environment. The most immediate changes required to support extrauterine life are concerned with respiration and the circulation. The infant must be able to expand its lungs fully and at the same time the pulmonary circulation must be adequate for gaseous exchange to occur between the air spaces and the pulmonary capi...