Several inflammatory markers have been investigated as prognostic parameters in a variety of cancer population with mostly favorable results. This study aimed to verify the significance of common inflammatory markers as prognostic variables and assess whether a selective combination of them as prognostic inflammation score (PIS) could further improve their prognostic values in surgical patients...

Proteasome inhibitors (PI), a novel class of anticancer drugs, are relatively well tolerated and have recently been introduced into the clinic for the treatment of multiple myeloma. The tumor selectivity and low toxicity of PIs are surprising, given the crucial role of the ubiquitin/proteasome system in a multitude of cellular processes. Here, we show that systemic administration of PIs specifi...

BACKGROUND The present study (1) compared the ability of power Doppler imaging with that of gray-scale B-mode tissue imaging to opacify the myocardium and detect coronary stenosis by myocardial contrast echocardiography and (2) compared the response of video intensity (VI) to variable pulsing intervals for each modality. METHODS AND RESULTS Four grades of left anterior descending coronary art...

Demand response (DR) programs have been growing in number and magnitude in the past decade to reduce load during the peak hours. Despite efforts to automate DR, we lack methods and tools to support facility/building managers with ‘how to respond’ decisions at building-scale. This is because there are multiple control strategies available at commercial buildings as response to a DR signal and qu...

The Prescribing Information System (PIS) provides an infrastructure for pharmacoepidemiology and pharmacovigilance research, attracting growing attention due to its unique combination of characteristics. Compared with several databases worldwide offering national population coverage and record linkage, PIS covers all National Health Service (NHS) prescriptions prescribed, dispensed and reimburs...

Flexible Manufacturing System provides many alternative machines and conveying paths to manufacture a given part. Thus control of such complex systems must be bent, via an effective Production Information System (PIS), to a powerful Decision Making System (DMS) which has to compute the best alternatives in real-time. This paper presents such a Production Information System (PIS) for Flexible Ma...

due to the increasing interest on renewable sources in recent years, the studies on integration of distributed generation to the power grid have rapidly increased. in order to minimize line losses of power systems, it is crucially important to define the size and location of local generation to be placed. minimizing the losses in the system would bring two types of saving, in real life, one is ...

BACKGROUND Asian Americans (AAs) and Native Hawaiians/Pacific Islanders (NHs/PIs) are the fastest growing segments of the US population. However, their population sizes are small, and thus AAs and NHs/PIs are often aggregated into a single racial/ethnic group or omitted from research and health statistics. The groups' substance use disorders (SUDs) and treatment needs have been under-recognized...