Sequencing Experiments in Drug Discovery Diana M. Negoescu Department of Management Science and Engineering, Stanford University, Stanford, CA 94305, USA, Peter I. Frazier School of Operations Research and Information Engineering, Cornell University, Ithaca, NY 14853, USA, Warren B. Powell Department of Operations Research and Financial Engineering Princeton University, Princeton, NJ 08544, USA...

There is a bewildering array of methods for estimating animal home ranges, including minimum convex polygons, bivariate ellipses, adaptive and fixed kernels, and even a Brownian bridge technique (Bullard 1991; Kernohan et al. 2001). Many people believe that the fixed kernel method using least-squares cross validation (LSCV) is the best approach currently available (Seaman and Powell 1996; Powel...

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In this paper we construct C continuous piecewise quadratic hierarchical bases on Powell–Sabin triangulations of arbitrary polygonal domains in R. Our bases are of Lagrange type instead of the usual Hermite type and we prove that they form strongly stable Riesz bases for the Sobolev spaces Hs(Ω) with s ∈ (1, 5 2 ). Especially the case s = 2 is of interest, because we can use the corresponding h...