Polyols are important metabolites that often function as carbon and energy sources and/or osmoprotective solutes in some plants. In grapevine, and in the grape berry in particular, the molecular aspects of polyol transport and metabolism and their physiological relevance are virtually unknown to date. Here, the biochemical function of a grapevine fruit mesocarp polyol transporter (VvPLT1) was c...

the synthesis of twenty five esters of testosterone (17β -hydroxyandrost- 4-en-3-one) is described. all esters are derivatives of cycloalkycarboxylic acids. some of the esters possess α- , β -and/or & - substitution in the ester side-chain. the work was undertaken in order to evaluate long-acting male antifertility effect of such esters. most of the compounds, especially compound no.1, were fou...

Debaryomyces hansenii is a halotolerant yeast that produces and assimilates a wide variety of polyols. In this work we evaluate polyol transport in D. hansenii CBS 767, detecting the occurrence of polyol/H(+) (and sugar/H(+)) symporter activity, through the transient extracellular alkalinization of unbuffered starved cell suspensions. From the D. hansenii genome database, we selected nine ORFs ...

UNLABELLED Aims/Introduction:  The polyol pathway has long been involved in the pathogenesis of diabetic nephropathy. It remains still unclear, however, how the polyol pathway is implicated in this process. We explored the effects of the enhanced polyol pathway on renocortical tubular cells and glomeruli in experimentally-induced diabetes. MATERIALS AND METHODS   Transgenic mice (Tg) overexpr...

There is strong evidence to show that diabetes is associated with increased oxidative stress. However, the source of this oxidative stress remains unclear. Using transgenic mice that overexpress aldose reductase (AR) in their lenses, we found that the flux of glucose through the polyol pathway is the major cause of hyperglycemic oxidative stress in this tissue. The substantial decrease in the l...

 Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catecho...

Active eukaryotic RNA polymerase II (RNAP II) was purified by immunoaffinity chromatography, using a monoclonal antibody (mAb) that reacts with the highly conserved heptapeptide repeat of the largest subunit. This mAb (designated SWG16) was conjugated to CNBr-activated Sepharose and used to purify RNAP II from wheat germ and calf thymus. The subunit composition of the immunoaffinity-purified en...

a most effective and less energy demanding method of producing fatty esters, diol esters, by esterifying fatty acids, with neopentyl and ethylenglycol alcohols in the presence of an acidic ion exchange resin catalyst(polyestyrendivinylbenzensulfated) was investigated at elevated temperature. in this process an azeotroping agent, toluene, was used to facilitate continuous removal of water by dis...

The use of molecularly imprinted polymers in synthetic organic chemistry is reviewed. These materials are prepared in the presence of a template for which they carry a functional and stereochemical “memory” and can be likened to artificial antibodies or enzymes. Their unique properties have been exploited by the use of imprinted polymers as stereoand regio-selective solid supports in condensati...

The synthesis of twenty five esters of testosterone (17β -hydroxyandrost- 4-en-3-one) is described. All esters are derivatives of cycloalkycarboxylic acids. Some of the esters possess α- , β -and/or & - substitution in the ester side-chain. The work was undertaken in order to evaluate long-acting male antifertility effect of such esters. Most of the compounds, especially compound No.1, wer...