The cells of cerebrospinal fluid are usually examined in a Fuchs-Rosenthal chamber using a nuclear stain. By this means it is possible to distinguish between polymorphonuclear leucocytes and lymphocytes, but difficulties arise when other types of cell are predominant. If films can be made of a quality comparable with that expected for haematological diagnosis, various other cell types are found...

BACKGROUND Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether intra-articular administration of oligomycin, an inhibitor of mitochondrial function, induces an oxidative and inflammatory response in rat knee joints. METHODS Oligomycin was injected into the r...

A 63-yr-old male presented with a 20-day history of fever with chills, rigors, sweats and fatigue. He resided in the countryside and there was no history of recent travel to other countries. He had a past medical history of idiopathic pulmonary fibrosis (usual interstitial pneumonia confirmed by surgical biopsy) and the last 2 yrs he was taking daily azathioprine 100 mg per os and methylprednis...

BACKGROUND Infections related to stroke-induced immunodepression are an important complication causing a high rate of death in patients. Several experimental studies in mouse stroke models have described this process but it has never been tested in other species such as rats. METHODS Our study focused on the appearance of secondary systemic and pulmonary infections in ischemic rats, comparing...

Increasing evidence shows that inflammation plays a vital role in the occurrence and development of ischemia/reperfusion (I/R). Suppression of excessive inflammation can ameliorate impaired cardiac function, which shows therapeutic potential for clinical treatment of myocardial ischemia/reperfusion (MI/R) diseases. In this study, we investigated whether Ginkgolide C (GC), a potent anti-inflamma...

The observations of Collins (1937) and of Bennett, Zeller, and Bauer (1940) established clearly the pathological differentiation of the ordinary subcutaneous nodules in rheumatic fever and in rheumatoid arthritis. In brief, the rheumatic fever nodule is characterized by much fibrinoid material arranged in a lattice with apparently clear spaces between the strands, considerable oedema, but relat...

IT has already been shown in the two previous articles in this issue of the Journal that the clinical effects of cortisone and ACTH have excited much interest and a very extensive literature; the reports dealing with their effects upon the fundamental reactions of inflammation and repair, however, are as yet relatively few in number and there is still considerable disagreement over some of the ...

UNLABELLED The occurence of lung diseases (obstructive, malignant) resulting from smoking has an increasing tendency. The lung is the primary organ at risk from the effects of inhaled cigarette smoke and smoking has been implicated as a contributing factor to the causation of various respiratory diseases. The aim of presented work was to find out the subchronic effect of the 6-month exposure to...

IT has already been shown in the two previous articles in this issue of the Journal that the clinical effects of cortisone and ACTH have excited much interest and a very extensive literature; the reports dealing with their effects upon the fundamental reactions of inflammation and repair, however, are as yet relatively few in number and there is still considerable disagreement over some of the ...

P.M., a seventy year old Polish-born male clerk, was referred to the Hematology Clinic in September 1963. Examination in another medical service in 1961 had revealed moderate hepatosplenomegaly, a platelet count of 900,000 per cu.mm. with normal red and white blood cell counts, and megakaryocytic hyperplasia in bone marrow with excessive platelet production and hyperplasia of the white cell ser...