نتایج جستجو برای: polymeric prodrug

تعداد نتایج: 28114  

2012
Samit Kumar Yuvraj Singh Negi

Xylan, a green biopolymer extracted from agro-waste corn cob may be used as a tool to deliver drugs principally to the colon because of their timely retention in the physiological environment of stomach and small intestine and can only be degraded in colon by vast anaerobic microflora such as Bifidobacterium. Present research work relates to incorporate the drug molecule such as 5-aminosalicyli...

2015
Antonella Mangraviti Stephany Yi Tzeng Kristen Lynn Kozielski Yuan Wang Yike Jin David Gullotti Mariangela Pedone Nitsa Buaron Ann Liu David R. Wilson Sarah K. Hansen Fausto J. Rodriguez Guo-Dong Gao Francesco DiMeco Henry Brem Alessandro Olivi Betty Tyler Jordan J. Green

Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses for gene delivery; however, their use has been limited by poor efficacy in vivo. In this work, we synthesize and characterize polymeric gene delivery nanoparticles and evaluate their efficacy for DNA delivery of herpes simplex virus type I thymidine kinase (HSVtk) combined with the prodrug ganciclovir (...

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