We review recent progress in polymer-drug conjugate for cancer nanomedicine. Polymer-drug conjugates, including the nanoparticle prepared from these conjugates, are designed to release drug in tumor tissues or cells in order to improve drugs' therapeutic efficacy. We summarize general design principles for the polymer-drug conjugate, including the synthetic strategies, the design of the chemica...

Research in the field of polymers and polymeric materials has garnered immense attention past few decades due to versatile functional structural capabilities which often can be manipulated for applications therapy diagnosis a host diseases disorders. Polymer therapeutics comprises polymer-drug polymer-protein conjugates as well supramolecular systems used drug delivery systems. Although pharmac...

AIM To uptake and release hydrophilic model drugs and insulin in a novel conductive polymer (CP) nanotube transdermal patch. MATERIALS & METHODS The externally controlled transdermal delivery of model drugs and insulin were tested ex vivo and results were compared with CP films. The unique intrinsic properties of CPs provide electrostatic interaction between the model drugs and polymer backbo...

Nanotechnology is a relatively new branch of science that involves harnessing the unique properties of particles that are nanometers in scale (nanoparticles). Nanoparticles can be engineered in a precise fashion where their size, composition and surface chemistry can be carefully controlled. This enables unprecedented freedom to modify some of the fundamental properties of their cargo, such as ...

The colon targeted drug delivery system has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery system has recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and sma...

The colon targeted drug delivery system has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery system has recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and sma...

The colon targeted drug delivery system has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery system has recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and sma...

The concept of utilizing polymers in drug delivery has been extensively explored for improving the therapeutic index of small molecule drugs. In general, polymers can be used as polymer-drug conjugates or polymeric micelles. Each unique application mandates its own chemistry and controlled release of active drugs. Each polymer exhibits its own intrinsic issues providing the advantage of flexibi...

In this study, we have investigated the biodistribution and pharmacokinetic analysis of paclitaxel (PTX) and the apoptotic signaling molecule, C6-ceramide (CER), when administered in a multifunctional polymer-blend nanoparticle formulation to female nude mice bearing an orthotopic drug sensitive MCF7 and multidrug resistant MCF7 TR (MDR-1 positive) human breast adenocarcinoma. A polymer-blend n...