Functionalization of a porous orthopedic implant with dexamethasone, a widely used anti-inflammatory drug, encapsulated within a biodegradable polymer for controlled release could help reduce or eliminate the inflammation response by the local tissue. In this research, we investigated the possibility of using supercritical carbon dioxide (CO₂) for attaching dexamethasone-loaded PLGA (polylactic...

Chlorella pyrenoidosa were allowed to photosynthesize for short periods of time in the presence of (14)CO(2) and HTO. Analysis of tritium and (14)C labeling of photosynthetic intermediate compounds showed that the T/(14)C ratio of glycolic acid was comparable to that of intermediate compounds of the photosynthetic carbon reduction cycle when photosynthesis was performed in nearly 100% oxygen an...

  Objective: In dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. In this study, gentamicin was loaded into polylactic co-glycolic acid (PLGA) microspheres and its release pattern was evaluated for 20 days.   Methods: In this experimental study, PLGA microspheres loaded with gentamycin were produced by the W/O/W method....

Ammonium glycolate combustion was used to synthesize SrZr0.95Y0.05O3−x powders. Soluble metal-glycolate complexes, detected by infrared spectroscopy, were formed with Y+3 and Zr+4, which maintain atomic level mixing of metal cations with glycolic acid. Sr+2/glycolic acid mixtures did not form glycolate complexes. Temperature-programmed reaction studies showed that only precursor solutions with ...

Poly(lactic acid) (PLA) is the most promising biodegradable alternative to replace conventionalpetrochemical-based polymers in manufacturing high performance materials. Here we review main methods obtain polylactic acid and briefly discuss its functionalization application field of controlled drug release. We conducted a bibliographic search scientific databases summarized results research carr...

In treatment of diabetes, it is much desired in clinics and challenging in pharmaceutics and material science to set up a long-acting drug delivery system. This study was aimed at constructing a new delivery system using thermogelling PEG/polyester copolymers. Liraglutide, a fatty acid-modified antidiabetic polypeptide, was selected as the model drug. The thermogelling polymers were presented b...