Polybrominated biphenyl (PBB), a flame-retardant material, was introduced into the food chain in Michigan in 1973 due to a manufacturing and distribution mistake. Following public concern about the long-term health effects of PBB in humans, a cohort of PBB-exposed Michigan residents was assembled in 1975. We initiated this study to determine the half-life of PBB in human sera and to understand ...

Results of serum PBB determinations on 524 Michigan diary farm residents and consumers of products from the farms, 55 chemical workers, and 56 Wisconsin farm residents are reported. Mean and median values were highest for the chemical workers, followed by consumers from and residents of quarantined and nonquarantined farms. Serum DDE was higher among chemical workers, but was similar for all ot...

Induction of Drug-Metabolizing Enzymes by Fractionated Commercial Polybrominated Biphenyls (PBBs). ROBERTSON, L., PARKINSON, A., AND SAFE, S. (1981). Toxicol. Appl. Pharmacol. 57, 254-262. A commercial polybrominated biphenyl mixture was separated chromatographically into two fractions on neutral alumina (AA and A,) and into three fractions on Florisil (FA, Fa, and Fc) by sequential elution wit...

Antibodies against cytochromes P-450a, P-450b + P450e, P-450c, and P-450d and epoxide hydrolase were utilized in a radial immunodiffusion assay to measure the concentration of these inducible, xenobiotic-metabolizing enzymes in liver microsomes from rats treated with Aroclor 1254, fireMaster BP-6, or one of 41 individual polychlorinated and polybrominated biphenyl isomers and congeners. Cy...

Various classes of persistent halogenated compounds (PHCs) can be released into the environment due to improper handling and disposal of electronic waste (e-waste), which creates severe environmental problems and poses hazards to human health as well. In this review, polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs), tetrabromobisphenol A (TBBPA), polybrominated phenols (P...

Family clustering of varying levels of serum PBB and DDE was evaluated for 62 Michigan families by using the mean and standard deviation for family units, ranked percentile comparison of family members, and correlation by linear regression of family members. The results indicate that levels of serum PBBs cluster within family units and for children within families. Serum DDE clustering within f...

The effect of copper and its compounds on halogenation dehalogenation aromatic will be discussed in the proposed article. Cu oxidized to appropriate halides is an effective catalyst not only for synthesis halogenated benzenes or their derivatives as desired organic fine chemicals, but also undesirable formation thermodynamically stable very toxic polychlorinated polybrominated such biphenyls, d...