Polyarteritis nodosa (PAN) is regarded rightly as the grandfather of the vasculitides. In this Grand Rounds, the case of a 30-year-old man with a 12-year illness is described. The patient presented with daily fevers, tachycardia, and cutaneous ulcers on his distal extremities. He eventually developed mononeuritis multiplex. Because of the striking pattern of his fevers, he was diagnosed for man...

A 64-year-old man was admitted for alithiasic cholecystitis. Necrotizing vasculitis was detected in a gallbladder obtained at the cholecystectomy. Slight elevation of transaminases, HBe antigens and hepatitis B-DNA (HBV-DNA) were detected in the patient. Intrahepatic necrotizing vasculitis was also detected in the liver biopsy specimen, and he also suffered from peripheral neuropathy of suddenl...

Polyarteritis nodosa (PAN) causes necrotizing angitis mainly in medium-sized muscular arteries throughout the body, and various clinical signs and symptoms such as fever, malaise, weight loss, skin necrosis, renal failure, cerebral nervous system disorder, heart failure, and myalgia develop in affected patients. However, otolaryngologists rarely encounter patients with polyarteritis nodosa, exc...

We describe a patient with discoid lupus erythematosus whose pattern of disease evolved into a systemic vasculitis polyarteritis nodosa.

Cutaneous polyarteritis nodosa (CPN) is an uncommon form of vasculitis. It exists as a separate entity, though bearing similar name with polyarteritis nodosa (PAN) which is an aggressive systemic vasculitis with multi-organ involvement. CPN runs a chronic but benign course. Its aetiology is unknown and it usually presents with painful nodules on the legs with mild constitutional symptoms, and e...

cPAN: cutaneous polyarteritis nodosa IL: interleukin pANCA: perinuclear antineutrophil cytoplasmic antibodies INTRODUCTION Cutaneous polyarteritis nodosa (cPAN) is a vasculitis of medium-sized arteries in the dermis and subcutaneous tissues. Etiology is currently unknown, although it may be immune complex mediated and has been linked to various infections, drugs, and autoimmune diseases. Dermat...

INTRODUCTION Polyarteritis nodosa can on rare occasions manifest itself as vasculitis of the gallbladder. Patients typically present with right upper quadrant pain and are initially worked up for cholecystitis. The definitive diagnosis is then usually based on surgical and histopathological findings. CASE PRESENTATION In this case a 23-year-old Caucasian female presented with a 3 week history...

Polyarteritis Nodosa (PAN) is a vasculitis of unknown origin that affects the medium and small arteries of our organ system. Isolated Polyarteritis Nodosa is a rare condition that may be due to modulation of local immune reaction by exposure to certain local triggering agent without any systemic immune reaction. Symptomatic PAN confined to the testis in hepatitis B infection is extremely rare a...

A 37-year-old Chinese male presented with an acute abdomen. Surgical exploration revealed duodenal perforation, extensive small bowel infarction and peritonitis. Histopathology of the resected bowel showed characteristic features of classic polyarteritis nodosa. The latter also involved mesenteric arteries in the form of tiny aneurysms. Steroids could not be started due to: (i) overwhelming mic...