نتایج جستجو برای: poly ß
تعداد نتایج: 84399 فیلتر نتایج به سال:
Mouse fibroblasts, deficient in DNA polymerase ß (ß-pol), are hypersensitive to monofunctional DNA methylating agents such as methyl methanesulfonate (MMS). Both wild-type, and in particular repair deficient ßpol null cells, are highly sensitized to the cytotoxic effects of MMS by 4-amino-1,8naphthalimide (4-AN), an inhibitor of poly(ADP-ribose) polymerase (PARP) activity. Experiments with sync...
The fungus Penicillium purpurogenum was found to produce intracellular ß-glucosidase. Maximum activity of ß-glucosidase was observed on sucrose. Various cultural parameters of cultivation of P. purpurogenum for production of ß-glucosidase were optimized. Maximum enzyme content was observed after 96 hours of cultivation at 30°C. Addition of amino acids histidine and cysteine induced ß-glucosidas...
It has been shown that inflammation reduces the effectiveness of sympathetic nerves in the regulation of knee joint blood flow, and the joint vascular- ß adrenoceptors are changed due to acute inflammation from a majority of ß-1 to an equality of ß-1 and ß-2 receptors.. To investigate the role of sympathetic nerves in nerve induced vasoconstriction and changes in joint vascular ß-adrenoceptors ...
برهمکنش پورفیرازین کاتیونی تتراکیس(n,n,n,n -4,3-تتراپیریدینو) روی(ii) (zn(tmtppa))با پلی نوکلئوتیدهای سنتزی: poly[d(g-c)]2 و poly[d(a-t)]2 و dna غده تیموس گوساله در بافر فسفات 5/7 میلی مولار با ph 2/7 با استفاده از تکنیک های اسپکتروسکوپی جذب نوری و فلورسانس مطالعه شده است. کاهش جذب بیشتر از % 40 در طیف uv-vis پورفیرازین به دلیل برهمکنش با هر دو پلی نوکلئوتیدهای poly[d(g-c)]2 و poly[d(a-t)]2 م...
Wnt/ß-catenin signaling is strongly implicated in neoplasia, but the role of this pathway in human breast cancer has been controversial. Here, we examined Wnt/ß-catenin pathway activation as a function of breast cancer progression, and tested for a relationship with HER2/neu expression, using a human tissue microarray comprising benign breast tissues, ductal carcinoma in situ (DCIS), and invasi...
برهمکنش پورفیرازین کاتیونی تتراکیس(n,n,n,n 3و4-تتراپیریدینو) کبالت(ii) (co(tmtppa))با پلی-نوکلئوتیدهای سنتزی: poly(g-c) و poly(a-t) و dna غده تیموس گوساله در بافر فسفات 5/7 میلی مولار با ph 2/7 با استفاده از تکنیک های اسپکتروسکوپی جذب نوری و فلورسانس مطالعه شده است. کاهش جذب و جابجایی قرمز در طول .موج طیف uv-vis پورفیرازین به دلیل برهمکنش با هر دو پلی نوکلئوتیدهای poly(g-c) و poly(a-t) مشاهده...
1 Downregulation of Cdk6 kinase activity is crucial for TGF-ß induced growth inhibition (I) ………………………………………………………………………………….38 1.1 TGF-ß growth inhibition is attenuated by overexpression of wild type Cdk6 …………38 1.2 Cyclin D-related kinase activity is maintained in wild type Cdk6-overexpressing cells treated with TGF-ß …..……………………………………………………………….39 1.3 Cdk2-associated kinase activity is partia...
Complexation of celecoxib with ß-cyclodextrin and hydroxypropyl-ß-cyclodextrin in the presence and absence of polyvinylpyrrolidone and the effect of polyvinylpyrrolidone on the solubilizing efficiency of cyclodextrins and on the dissolution rate of celecoxib from the cyclodextrin complexes were investigated. The phase solubility studies indicated the formation of celecoxib-ß-cyclodextrin and ce...
Glucocorticoids (GCs) are well known to induce insulin resistance. However, the effect of GCs on insulin secretion has not been well characterized under physiological conditions in human. We here evaluated the effect of GCs on insulin secretion/ß-cell function precisely in a physiological condition. A population-based study of 1,071 Japanese individuals enrolled in the 2014 Iwaki study (390 men...
The multifunctional protein ß-catenin governs as transcription factor the expression of a wide variety of genes relevant for cell proliferation and cell survival. In addition, ß-catenin is localized at the cell membrane and may influence the function of channels. The present study explored the possibility that ß-catenin participates in the regulation of the HERG K(+) channel. To this end, HERG ...
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