Research of protein is pivotal to the drug discovery, since most of the drugs act upon proteins inside human body. Drugs act when they are close to the concave portions, so called “pockets”, of protein surfaces. Therefore, detection and analysis of the pockets are also important for the drug discovery. This paper presents a fast pocket extraction and evaluation technique for protein surfaces. S...

Molecular surfaces of proteins and other bio-molecules, while modeled as smooth analytic interfaces separating the molecule from solvent, often contain a number of pockets, holes and interconnected tunnels, aka molecular features in contact with the solvent. Several of these molecular features are biochemically significant as pockets are often active sites for ligand binding or enzymatic reacti...

In This Issue In This Issue RB pockets the cell cycle idely used cancer therapies inflict collateral damage on normal dividing cells. But now Lohez et al. (page 67) find a way to distinguish normally cycling cells from cancer cells using actin inhibitors that cause an RB-dependent cell cycle arrest. High levels of actin inhibitors prevent cell cleavage and thus lead to a doubling of cellular DN...

BACKGROUND Periodontal disease or periodontitis is an inflammatory disease with a hight prevalence. According to the last oral health survey of the Spanish population, between 24% and 37% of Spaniards aged over 35 years have periodontitis and 6% to 10% of the adult population have deep periodontal pockets. The aim of this study was to determine the association between risk factors and the prese...

georgia is a country with a human development index (hdi) score of 0.733. significant deterioration in socio-economic conditions in the 1990s caused serious health problems in the population including oral health. since then, there has not been an epidemiological survey of dental diseases among the adult population in georgia.the pathfinder survey- cluster- stratified method derived by who was ...

OBJECTIVES The aim of the study was to investigate the clearance of PVP-iodine applied as a gel or solution in periodontal pockets. METHODS Teeth of 12 subjects with at least eight periodontal pockets of ≥5 mm probing depth were isolated with a rubber dam to allow contamination-free access to the pockets. In each subject, three pockets were filled with PVP-iodine gel (10%) and three with PVP-...