OBJECTIVE To evaluate the effect of pneumoperitoneum, both alone and in combination with controlled ventilation, on peritoneal lymphatic bacterial clearance using a rat bacterial peritonitis model. METHOD A total of 69 male Wistar rats were intraperitoneally inoculated with an Escherichia coli solution (10(9) colony-forming units (cfu)/mL) and divided into three groups of 23 animals each: A (...

signs were observed in 5 (55.5%) patients, with fever reported in 4, abdominal tenderness in 4, and leukocytosis in 4. Two patients (22.2%) with moderate (2−4 cm) or large (>4 cm) pneumoperitoneum after PEG died from either pneumonia or septic shock. The authors concluded that the clinical course of pneumoperitoneum after PEG is not always benign and self-limited, and therefore a moderate or la...

Pneumoperitoneum is defined as the presence of free air in abdominal cavity. The most common cause pneumoperitoneum intestinal perforation, which usually requires surgical intervention. Nonsurgical (NPS) cavity without visceral perforation by an intrathoracic route, commonly occurs patients on mechanical ventilation intensive care units. NSP, when properly diagnosed, can be successfully treated...

BACKGROUND Peritoneal absorption of CO(2) during abdominal insufflation in laparoscopy may disrupt the acid-base equilibrium and alter the physiological response to stress. Current nonventilated rodent models of laparoscopy do not manage the CO(2) load of pneumoperitoneum, but ventilated surgical rodent models are invasive (tracheotomy) and may independently induce the inflammatory response. ...

BACKGROUND Acute kidney injury (AKI) following prolonged laparoscopy is a documented phenomenon. Carbon dioxide pneumoperitoneum induces oxidative stress. Previous experimental studies have shown that the antioxidant, N-acetylcysteine, protects the rat from AKI following ischemia-reperfusion. The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) on rat renal function after...

BACKGROUND Robot-assisted laparoscopic radical prostatectomy and robot-assisted radical cystectomy have gradually become the preferred choices for urologists as they allow surgeons to perform complex procedures more precisely and effectively. The pneumoperitoneum, which is normally applied in these surgeries to provide visual clarity and space to perform the procedure, may cause hemodynamic dis...

BACKGROUND The induction of the pneumoperitoneum increases intraabdominal pressure (IAP), causing splanchnic ischemia, whereas its deflation normalizes IAP and splanchnic blood flow. We investigated the oxidant-antioxidant status of dogs who underwent low pressure (7 mm Hg), standard pressure (12 mm Hg), and high pressure (15 mm Hg) pneumoperitoneum. RESULTS Twenty-four beagle dogs (12 males ...

BACKGROUND Positive end-expiratory pressure (PEEP) can increase intracranial pressure. Pneumoperitoneum and the Trendelenburg position are associated with an increased intracranial pressure. We investigated whether PEEP ventilation could additionally influence the sonographic optic nerve sheath diameter as a surrogate for intracranial pressure during pneumoperitoneum combined with the Trendelen...

Pneumoperitoneum in the neonate generally is an acute surgical emergency, which has grave implications, and immediate surgical intervention is needed to ensure survival. The most common cause is a perforated hollow viscus. However, there are causes that cannot be attributed to this etiology, constituting what has been called non-surgical, asymptomatic, benign, misleading, spontaneous or idiopat...