Xerosis is a common skin condition as well key aspect of number diseases associated to hereditary and acquired conditions. The objective this study was formulate evaluate the pluronic lecithin organogel containing natural moisturizing agents for topical application. Different formulations organogels were prepared by using Pluronic F127, Lecithin, Vitamin E, Aloe vera, water, sorbic acid, potass...

conclusions results showed that hcvcp + bcg induced a moderate ctl and mixed th1/th2 immune responses with higher levels of cell proliferation and ifn-γ secretion, indicating that bcg may have a better outcome when formulated in hcvcp-based subunit vaccines. results expression and purification of core protein around the expected size (21 kda) was confirmed by western blotting. the hcvcp + bcg v...

A simple and novel approach was developed to obtain water-dispersible silicon quantum dots (Si-QDs) of low toxicity that were able to selectively label the endoplasmic reticulum (ER) in live cells. A block copolymer (Pluronic F127) was used to coat the surface of Si-QDs. Si-QDs form aggregates with diameters of 20-40 nm and show an outstanding optical stability upon UV irradiation. Our F127-tre...

Multi-stimuli responsive hydrogels are synthesized using self-assembled nanomicelles of Pluronic F127 diacrylate triblock copolymer as non-covalent macro-crosslinkers to in situ copolymerize with acrylamide and methyl chloride quaternized N,N-dimethylamino ethylacrylate monomers, generating positively charged hydrogels. These hydrogels showed high strength, toughness, and outstanding fatigue re...

This work evaluated the potential of Pluronics (varieties F127 and P123) in combination with solubilizing agents to be used as syringeable in situ gelling depots of intratumoral β-lapachone (βLAP). Pluronic dispersions prepared at various concentrations in the absence and the presence of ethanol and randomly methylated β-cyclodextrin (RMβCD) were characterized regarding their rheological proper...

Demineralized bone matrix (DBM) is widely used for bone regeneration. Since DBM is prepared in powder form its handling properties are not optimal and limit the clinical use of this material. Various synthetic and biological carriers have been used to enhance the DBM handling. In this study we evaluated the effect of gamma irradiation on the physical-chemical properties of Pluronic and on bone ...

PURPOSE To develop an in situ gel system comprising liposome-containing paclitaxel (PTX) dispersed within the thermoreversible gel (Pluronic® F127 gel) for controlled release and improved antitumor drug efficiency. METHODS The dialysis membrane and membrane-less diffusion method were used to investigate the in vitro drug release behavior. Differential scanning calorimetry (DSC) thermal analys...

Surface tension (ST) measurements were carried out on various binary mixtures of the "normal" surfactants, such as nonionic surfactant, hexaethylene glycol mono-n-dodecyl ether(C12EO6), and cationic surfactant, tetradecyltrimethylammonium bromide (TTAB), and polymeric copolymer, Pluronic F127, F127(PPO)-g-PVP, and F127(PEO)-g-PVP. In all cases mixed micellar aggregates were formed and critical ...

In order to apply curcumin as a photosensitizer in photodynamic therapy (PDT) one needs a formulation that can solubilize and stabilize the compound. Pluronics® (Pluronic) are reported to both solubilize and stabilize curcumin against hydrolytic degradation. The aim of the present work was therefore to investigate the influence of Pluronic formulation on the photocytotoxicity of curcumin. Inter...

Pluronic F127 exhibits thermogelling behaviour at 20–30 ◦C via a micelle packing mechanism. Disruption of the micelle packing increases the sol-gel temperature, but results in the decrease of modulus. Herein, we reported a method to modify F127 with polyhedral oligosilsesquioxane (POSS) to impart a higher gelling temperature without yielding the property and strength of the thermogel. The therm...