PURPOSE To report a case of extrusion of a new soft punctum plug with thermoexpansion property (Medennium SmartPLUG). METHODS A soft punctum plug was implanted in a 32-year-old woman with a severe dry eye syndrome in juvenile arthritis. RESULTS One week after implant the plug partially extruded outside the punctum. Despite this adverse event, all subjective dry eye symptoms improved. CONC...

Software component architectures allow assembly of applications from individual software modules based on clearly defined programming interfaces, thus improving the reuse of existing solutions and simplifying application development. Furthermore, the plug-in programming paradigm additionally enables runtime reconfigurability, making it possible to adapt to changing application needs, such as di...

Spamato is an extendable, collaborative spam filter system written in Java that combines different filter technologies to provide more accurate results. This thesis takes Spamato a big step further by introducing a plug-in architecture. Users and developers can now customize their system by adding, updating, and removing plug-ins. The underlying plug-in architecture is completely independent of...

Proteins are translocated across membranes through a channel that is formed by the prokaryotic SecY or eukaryotic Sec61 complex. The crystal structure of the SecY channel from M. jannaschii revealed a plug domain that appears to seal the channel in its closed state. However, the role of the plug remains unclear, particularly because plug deletion mutants in S. cerevisiae are functional. Here, w...

Problem Statement: The evolution of software is made difficult by the need to integrate new features with all previously implemented features in software applications. Approach: present study introduced a general-purpose, platform-independent object-oriented design metric plug-in framework called jmetric intended to help building scalable, extendable object-oriented design metric plug-ins. jmet...

This paper proposes plug-in bandwidth selection for kernel density estimation with discrete data via minimization of mean summed square error. Simulation results show that the plug-in bandwidths perform well, relative to cross-validated bandwidths, in non-uniform designs. We further find that plug-in bandwidths are relatively small. Several empirical examples show that the plug-in bandwidths ar...

Plug-in frameworks support the development of component-based software that is extensible and customizable to the needs of specific users. However, most current frameworks are targeting single-user rich client applications but do not support plug-in-based web applications which can be extended by end users. We show how an existing plug-in framework (Plux.NET) can be enabled to support multi-use...