We identified a novel mutation in members of a family with signs of Crouzon syndrome and plagiocephaly. In affected members of the family an A-->G transition was found at position 886 in exon 5 of the fibroblast growth factor receptor 2 (FGFR2) gene. The base change results in the replacement of a lysine by glutamic acid in Ig-like loop III of FGFR2. The unusual finding of plagiocephaly in thes...

OBJECTIVE This study was designed to statistically evaluate the independent and interacting effects of biological and environmental risk factors that influence lateralization of deformational plagiocephaly (DP) in an attempt to provide future guidance for clinical treatment. METHODS A database of >20000 children treated for DP was examined by using 2- and 3-way factor analyses for categorical...

Plagiocephaly is a common asymmetry of the skull which looks as if it has been compressed along a horizontal axis between one temple and the opposite side of the occiput. It is often seen in normal people, and is only very rarely due to underlying disease or malformation of the skull; such cases are not discussed here. The observation of plagiocephaly in a few children seen because of congenita...

OBJECTIVE To study the effect of pediatric physical therapy on positional preference and deformational plagiocephaly. DESIGN Randomized controlled trial. SETTING Bernhoven Hospital, Veghel, the Netherlands. PARTICIPANTS Of 380 infants referred to the examiners at age 7 weeks, 68 (17.9%) met criteria for positional preference, and 65 (17.1%) were enrolled and followed up at ages 6 and 12 m...

Over the past decade there has been a dramatic increase in referrals to specialty clinics, craniofacial centers, plastic surgeons, and neurosurgeons for assessment and treatment of deformational plagiocephaly (DP). Though considered a medically benign condition, preliminary reports suggest that DP may be associated with developmental problems. However, mechanisms to account for this association...

OBJECTIVE There has been a large increase in reported cases of nonsynostotic plagiocephaly in infants since the adoption of supine sleeping recommendations to prevent sudden infant death syndrome. The objective of this study was to identify and quantify the determinants of nonsynostotic plagiocephaly in infants. METHODS One hundred infants who received a diagnosis of having nonsynostotic plag...

OBJECTIVE This study was designed to evaluate the effectiveness of helmet therapy (DOC band) in the correction of patients with moderate to severe posterior deformational plagiocephaly. DESIGN In this prospective study, the infants were evaluated using 18 anthropometric measurements. PATIENTS The charts of 248 patients seen between August 1, 1995, and July 31, 1999, were reviewed, and 125 m...