To achieve sustained release of 3-ethyl-4-(4-methylisoxazol-5-yl)-5-(methylthio) thiophene-2-carboxamide (BFB0261), a new potent osteogenic compound for treating bone disorders, we prepared film formulations containing BFB0261 and the following newly synthesized biodegradable polymers by a solvent casting technique: poly(D,L-lactic acid) (PLA), poly(D,L-lactic acid-co-glycolic acid) (PLGA), pol...

Mammalian Group IIA phospholipases A(2) (PLA(2)) potently kill Staphylococcus aureus. Highly cationic properties of these PLA(2) are important for Ca(2+)-independent binding and cell wall penetration, prerequisites for Ca(2+)-dependent degradation of membrane phospholipids and bacterial killing. To further delineate charge properties of the bacterial envelope important in Group IIA PLA(2) actio...

A renewable resource, epoxidized jatropha oil (EJO), was used as a green plasticizer and added to poly(lactic acid) (PLA). EJO was compounded into PLA at different contents. The addition of 3 wt % EJO to the PLA demonstrates significant improvement in flexibility, which leads to a percentage increase of about 7000% in elongation at break. This tensile result was confirmed by surface morphology ...

Cinnamaldehyde (CA) was successfully encapsulated in β-cyclodextrin (β-CD), and polylactic acid (PLA)-based composite fibers were prepared by incorporating CA/β-CD via electrospinning. Morphological, structural, spectral, and antibacterial properties of different weight ratios of PLA:β-CD/CA (88:12, 94:6, 97:3, and 98.5:1.5) and PLA/CA/β-CD fibers were investigated. PLA and CA/β-CD were incorpo...

Several lines of evidence indicate that phospholipase A(2) (PLA(2)) plays a crucial role in plant cellular responses through production of linolenic acid, the precursor of jasmonic acid, from membrane phospholipids. Here we report the purification and characterization of a 48-kD PLA(2) from the membrane fractions of leaves of broad bean (Vicia faba). The plant PLA(2) was purified to near homoge...

Phospholipase A(2)s (PLA(2)s) constitute a family of enzymes that hydrolyze fatty acids of membrane phospholipids, thus initiating the synthesis of proinflammatory mediators. Various PLA(2)s have been detected in human atherosclerotic arteries (advanced lesions); however, only the secretory group of PLA(2) has been shown to specifically hydrolyze low density lipoprotein (LDL)-associated phospho...

fatty acid modified cellulose nanofibers (mcnfs) and tbhq antioxidant were added to poly(lactic acid) (pla) film. the combined effects of the mcnfs and tbhq on the morphological, thermal, mechanical and barrier properties of pla film were analyzed. the morphology of fracture surfaces evaluated by field emission scanning electron microscopy (fe-sem). xrd results showed that the crystallinity of ...

Pyogenic liver abscess (PLA) is a common intra-abdominal infection in adults. In this study, we aim to explore demographic and clinical characteristics of PLA focusing on Klebsiella pneumoniae (K. pneumoniae) induced PLA (KP-PLA) in mainland China. A retrospective review of medical records from all patients with KP-PLA admitted to a tertiary teaching hospital over a 21-year period (1994-2015) w...

PURPOSE To determine the effects of whey protein before and during resistance exercise (RE) on body composition and strength in young adults. METHODS Participants were randomized to ingest whey protein (PRO; 0.3 g/kg protein; n = 9, 24.58 ± 1.8 yr, 88.3 ± 17.1 kg, 172.5 ± 8.0 cm) or placebo (PLA; 0.2 g/kg cornstarch maltodextrin + 0.1 g/kg sucrose; n = 8, 23.6 ± 4.4 yr, 82.6 ± 16.1 kg, 169.4 ...

BACKGROUND Pyogenic liver abscesses (PLA) remain a significant clinical problem. Unfortunately, little is known about current bacterial susceptibility profiles and the incidence of multidrug resistant organisms (MDROs) causing PLA in Western countries. Yet, this crucial information is pivotal to guide empirical antibiotic therapy. Aim of this study was to provide detailed characteristics of PLA...