نتایج جستجو برای: pkd2

تعداد نتایج: 596  

Journal: :Neuro-oncology 2011
Ninel Azoitei Alexander Kleger Nina Schoo Dietmar Rudolf Thal Cornelia Brunner Ganesh Varma Pusapati Alina Filatova Felicitas Genze Peter Möller Til Acker Rainer Kuefer Johan Van Lint Heinrich Baust Guido Adler Thomas Seufferlein

Glioblastoma multiforme, a highly aggressive tumor of the central nervous system, has a dismal prognosis that is due in part to its resistance to radio- and chemotherapy. The protein kinase C (PKC) family of serine threonine kinases has been implicated in the formation and proliferation of glioblastoma multiforme. Members of the protein kinase D (PKD) family, which consists of PKD1, -2 and, -3,...

Journal: :Development 2007
Jodi Schottenfeld Jessica Sullivan-Brown Rebecca D Burdine

The zebrafish mutation curly up (cup) affects the zebrafish ortholog of polycystic kidney disease 2, a gene that encodes the Ca(2+)-activated non-specific cation channel, Polycystin 2. We have characterized two alleles of cup, both of which display defects in organ positioning that resemble human heterotaxia, as well as abnormalities in asymmetric gene expression in the lateral plate mesoderm (...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Ivana Y Kuo Andrea T Kwaczala Lily Nguyen Kerry S Russell Stuart G Campbell Barbara E Ehrlich

Cardiac disorders are the main cause of mortality in autosomal-dominant polycystic kidney disease (ADPKD). However, how mutated polycystins predispose patients with ADPKD to cardiac pathologies before development of renal dysfunction is unknown. We investigate the effect of decreased levels of polycystin 2 (PC2), a calcium channel that interacts with the ryanodine receptor, on myocardial functi...

Journal: :Journal of the American Society of Nephrology : JASN 1995
M A van Dijk P C Chang D J Peters M H Breuning

Autosomal dominant polycystic kidney disease is genetically heterogenous, with at least two chromosomal loci accounting for the disease. When the mutation is located on chromosome 16 (PKD1), extra-renal manifestations such as the rupture of intracranial aneurysms are well known. In the case of localization on chromosome 4 (PKD2), in which the renal disease runs a milder course, not much is know...

Journal: :Blood 2011
Hui Zheng Juan Qian Christopher J Carbone N Adrian Leu Darren P Baker Serge Y Fuchs

Angiogenesis is stimulated by vascular endothelial growth factor (VEGF) and antagonized by type 1 interferons, including IFN-α/β. On engaging their respective receptors (VEGFR2 and IFNAR), both stimuli activate protein kinase D2 (PKD2) and type 1 IFNs require PKD2 activation and recruitment to IFNAR1 to promote the phosphorylation-dependent ubiquitination, down-regulation, and degradation of th...

Journal: :Anticancer research 2013
Qin Hao Raymond McKenzie Huachen Gan Hua Tang

AIM The role of protein kinase D (PKD) in the context of breast cancer cell biology is not clear. MATERIALS AND METHODS The expression of PKD isoforms was assessed in various breast cancer cell lines and PKD isoform-specific siRNAs and selective inhibitors were used to study the role of PKD in breast cancer cell growth. RESULTS PKD2 and PKD3 were two major isoforms expressed at the highest ...

Journal: :Neuroscience Research 2015
Erda Avriyanti Nur Atik Masataka Kunii Naomi Furumoto Tomohiko Iwano Shin-ichiro Yoshimura Reiko Harada Akihiro Harada

Mammalian protein kinase D (PKD) isoforms have been proposed to regulate diverse biological processes, including the establishment and maintenance of neuronal polarity. To investigate the function of PKD in neuronal polarization in vivo, we generated PKD knockout (KO) mice. Here, we show that the brain, particularly the hippocampus, of both PKD1 KO and PKD2 KO mice was similar to that of contro...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2009
Mingqi Tan Feng Hao Xuemin Xu Guy M Chisolm Mei-Zhen Cui

OBJECTIVE Monocyte activation and migration are crucial events in the development of atherosclerosis and other inflammatory diseases. This study examined the role of protein kinase D (PKD) in monocyte migration. Method and Results- PKD2 is the predominant isoform of PKD expressed in monocytic THP-1 cells and primary human monocytes. Lysophosphatidylcholine (lysoPC), a prominent component of oxi...

2012
Atsushi Irie Kumiko Harada Norie Araki Yasuharu Nishimura

We previously reported that protein kinase D2 (PKD2) in T cells is promptly activated after T-cell receptor (TCR) stimulation and involved in the activation of interleukin-2 promoter and T cell death, and that one of its candidate substrate is SET protein, a natural inhibitor for protein phosphatase 2A (PP2A). In this study, we investigated the target amino acid residues of SET phosphorylated b...

Journal: :Molecular biology of the cell 2005
Alexandra Auer Julia von Blume Sabine Sturany Götz von Wichert Johan Van Lint Jackie Vandenheede Guido Adler Thomas Seufferlein

Protein kinase D2 (PKD2) belongs to the PKD family of serine/threonine kinases that is activated by phorbol esters and G protein-coupled receptors (GPCRs). Its C-terminal regulatory domain comprises two cysteine-rich domains (C1a/C1b) followed by a pleckstrin homology (PH) domain. Here, we examined the role of the regulatory domain in PKD2 phorbol ester binding, catalytic activity, and subcellu...

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