AIM To compare stress resistance increasing and analgesic activities of piperlongumine and a methanolic Piper longum fruit extract (PLE). METHODS Efficacies of a single and repeated daily oral doses (1-256 mg/kg/day) of PLE, piperlongumine, and 50 mg/kg/day doxycycline against foot shock stress triggered alteration in body weights and core temperatures, and of their 11 daily doses on antidepr...

This study was designed to evaluate pharmacokinetics of sulphadimidine   in cockerels fed on subclinical dose of arsenic (100 ppm) in diet and to determine the protective efficacy following simultaneous dietary medication with Piper longum (pipli)   (100 ppm) in a 12-week feeding trial. Pharmacokinetic parameters were determined after single i.v. dose (50 mg/kg) of sulphadimidine ...

Piperine, a crystalline alkaloid compound isolated from Piper nigrum, piper longum, and other types of piper, has had many fabulous pharmacological advantages for preventing treating some specific diseases, such as analgesic, anti-inflammatory, hepatoprotective, antimetastatic, antithyroid, immunomodulatory, antitumor, rheumatoid arthritis, osteoarthritis, Alzheimer's, improving the bioavailabi...

this study was designed to evaluate pharmacokinetics of sulphadimidine   in cockerels fed on subclinical dose of arsenic (100 ppm) in diet and to determine the protective efficacy following simultaneous dietary medication with piper longum (pipli)   (100 ppm) in a 12-week feeding trial. pharmacokinetic parameters were determined after single i.v. dose (50 mg/kg) of sulphadimidine in cockerels i...