BACKGROUND The HOXA10 homeobox gene controls embryonic uterine development and adult endometrial receptivity. The three-amino-acid loop extension (TALE) family homeobox genes like myeloid ecotropic viral integration site 1 (MEIS) provide enhanced target gene activation and specificity in HOX-regulated cellular processes by acting as HOX cofactors. METHODS AND RESULTS Analysis of an Affymetrix...

background: endometrial development has an important role in blastocyst adhesion and implantation. during ivf cycles, endometrial development is enhanced by progesterone. objective: the aim of this study was to compare ultrastructural and morphometrical characteristics of mice uterine endometrium in natural cycle with those in superovulated cycles received progesterone or sildenafil. materials ...

Background: Implantation is proceeded by a process referred as adhesion. Adhesion requires maturation of endometrium and blastocyst to confer adherence ability to them. During IVF cycles, endometrial maturation is facilitated by progesterone administrating. Considering vasodilatory effect of Sildenafild, in genital organs, it appears that Sildenafil may have similar effect as progestrone. The a...

Although pregnancy success rates are raised with assisted reproductive technology, it still cannot meet clinical demands. Kunling Pill (KLP), a traditional Chinese medicine, is widely used in various gynecological disorders, particularly improving fertility and rates. However, the underlying mechanism of how KLP affects outcomes remains unclear. This study aimed to explore effects mechanisms on...

OBJECTIVE To evaluate the clinical response and endometrial morphology during the implantation window on ovarian hyperstimulation with the aromatase inhibitor letrozole in infertile ovulatory women. DESIGN Prospective trial in infertile patients. SETTING Tertiary care hospital. PATIENT(S) Eight ovulatory infertile patient candidates for ovarian superovulation. INTERVENTION(S) Subjects w...

Embryo-endometrium crosstalk has a pivotal role during implantation. However, it is difficult to reveal the actual events and mechanisms involved in because of ethical technical limitations. On one hand, almost impossible conduct such experiments on human beings. other challenging establish an embryo-endometrium model mimic vivo process vitro. Endometrial glandular organoid culture been develop...

Infertility is an increasing medical and social problem affecting more than 10% of couples worldwide. Many underlying causes of human infertility have been overcome by assisted reproductive techniques; nevertheless, the implantation process remains one of the rate-limiting step as regards the success of the treatment. A prerequisite for successful implantation is the adequate preparation of a r...