Microarray gene expressions provide an insight into genomic biomarkers that aid in identifying cancerous cells and normal cells. In this study, functionally related genes are identified by partitioning gene data. Clustering is an unsupervised learning technique that partition gene data into groups based on the similarity between their expression profiles. This identifies functionally related ge...

Particle sorting methods in microfluidic platforms are gaining momentum for various biomedical applications. Bioparticles are found in different shapes and sizes. However, conventional separation techniques are mainly designed for separation of spherical particles. Thus, there is a need to develop new methods for effective separation of spherical and non-spherical bioparticles for various appli...

This paper aimed to analyze stress distribution in human zygomatic pillar during masseter muscle contraction using three-dimensional finite element analysis. A three-dimensional model and hemi facial skull were produced based on CT-scan data. An adult male skull with structural anatomy integrity was used as model. Muscles forces were applied at origin of elevator muscles and supports was applie...

An advantage of separation platforms based on deterministic micro- and nano-fabrications, relative to traditional systems based on packed beds of particles, is the exquisite control of all morphological parameters. For example, with planar platforms based on lithographically-prepared pillar arrays, the size, shape, height, geometric arrangement, and inter pillar gaps can be independently adjust...

This paper develops a formal model of banking regulation where the interactions between the 3 pillars of Basel 2 can be analyzed. It also provides a formal analysis of the mandatory subdebt proposal and shows that, under certain conditions, Pillar 1 (solvency ratio) and Pillar 3 (market discipline) are partially substitutable. The same is true for Pillar 2 (supervisory action) and Pillar 3. Mor...

Cochlear hair cells (HCs) are mechanosensory receptors that transduce sound into electrical signals. HC damage in nonmammalian vertebrates induces surrounding supporting cells (SCs) to divide, transdifferentiate and replace lost HCs; however, such spontaneous HC regeneration does not occur in the mammalian cochlea. Here, we acutely ablate the retinoblastoma protein (Rb), a crucial cell cycle re...

By observing gill blood flow using epi-illuminating microscopy, in parallel with cardiovascular recordings and immunohistochemistry, we have tried to identify the receptor mediating endothelin (ET) type 1 (ET1)-induced pillar cell contraction in the lamellae of the Atlantic cod (Gadus morhua). Intra-arterial injection of the specific ET(B) receptor agonist BQ-3020 induced dose-dependent increas...

We report the first synthesis of bridged pillararenes. Meso-form pillar[6]arenes were diastereo-selectively formed by bridging units of a per-hydroxylated pillar[6]arene in an alternating up-and-down manner with dialkyldichlorosilanes.