A multicentric noninterventional trial (open study without control) to investigate the efficacy and tolerance of a drug in a large number of patients under routine medical conditions was performed for a new solid preparation from an extract of the fruit of Vitex agnus castus (VAC, Vitex, chaste tree, Chasteberry) in 1634 patients suffering from premenstrual syndrome (PMS). A specific questionna...

Background: Most of the plant natural flora contributes significantly to medicinal benefits. To address shortcoming usage synthetic drugs, products are in demand which offer a broad spectrum activities with negligible side effects. Pinus succinefera is fossilized resin from coniferous woods that belongs genus Pinaceae family and widely known as Amber. The present study explores physiochemical p...

Citrullus colocynthis (L.) (C. colocynthis), commonly known as Handal in Yemen and other Arabic countries, is a plant with wide range of pharmacological properties. These properties are attributed to secondary metabolites, phytochemicals, present the plant. In this study, seed C. were extracted using dichloromethane, resulting oil extract was screened identify active phytoconstituents gas chrom...

Armenian flora is stood out by the variety of its medicinal and edible plants. Here small plants as well trees shrubs are met. Cotinus coggygria used in folk medicine. The aim this investigation was to determine chemical composition flora’s smoke leaves’ essential oil antiradical activity ethanol extract leaves branches tree. Methods: aerial parts were extracted hydrodistillation method, analyz...

Polyphenols, especially flavonoids, are well-known for their bioactive antioxidant properties. Therefore, this study aimed to analyze Australian black (ripe) and green olives (unripe) phenolic non-phenolic metabolites, activities, pharmacokinetic Liquid chromatography–mass spectrometry coupled with quadrupole–time of flight (LC–ESI–QTOF–MS/MS) was applied elucidate the composition, identificati...

The total flavonoid content (TFC), total polyphenols content (TPC), and in vitro antioxidant activity (AA) of six Bidens pilosa L., Asteraceae, populations harvested from different localities were evaluated in this work. The plants were separated in roots, stems, and leaves/flowers, and the influence of extraction methods was investigated. A reversed-phase high-performance liquid chromatography...

Luteolin 7-O-glucuronide, luteolin 7-O-glucurono-(1-->6)-glucoside, apigenin 7-O-glucuronide as well as free aglycones luteolin and apigenin have been isolated from lemon catnip herb (Nepeta cataria L. var citriodora). Luteolin 7-O-glucurono-(1-->6)-glucoside is probably a new compound, for the first time described. Two minor constituents of flavonoid fraction have been identified as apigenin 7...

BACKGROUND To-date modern drug research has focused on the discovery and synthesis of single active substances. However, multicomponent preparations are gaining increasing importance in the phytopharmaceutical field by demonstrating beneficial properties with respect to efficacy and toxicity. DISCUSSION In contrast to single drug combinations, a botanical multicomponent therapeutic possesses ...

AIM To investigate the effects of Ground Cherry (Physalis angulata L.) standardized supercritical CO2 extract in trinitrobenzenesulphonic acid (TNBS) model of rat intestinal inflammation. METHODS The animals were divided into groups that received vehicle or P. angulata extract (PACO2) orally at the doses 25, 50 and 100 mg/kg daily by 5 d before TNBS damage. Protective effects of PACO2 were as...