To express growth-related changes in physiologic or other functions in forms usable for kinetic modeling, we are interested in identifying regular relationships that take the form of simple mathematical expressions. Many anatomic and physiologic functions scale within or across species in accordance with the allometric relationship, y = axb. These include many organ weights, the glomerular filt...

1 GeIb AF, Tashldn DP, Epstein JD, Szeftel A, Fairshter R. Physiologic characteristics of malignant unilateral main-stem bronchial obstruction. Am Rev Respir Dix 1988; 138:1362-85 2 Gelb AF, Epstein JD. Laser in treatment oflung cancer. Chest 1984; 86:662-66 3 Healy F, Wilson AF, Fairshter RD. Physiologic correlates of airwaycollapse in chronic airfiowobstruction. Chest 1984; 85:47681 4 Jayaman...

variability of tidal volume and respiratory rate in normally breathing man has long been demonstrated [1]. however because of lack of knowledge and technology primary ventilators could only deliver a fixed tidal volume in a fixed rate the so called volume controlled ventilation (vcv). vcv was volume preset time triggered and cycled and there was no synchronization with patient’s breaths. at tha...

Background/Overview A variety of chemosensitivity and chemoresistance assays have been clinically evaluated in human trials. All assays use characteristics of cell physiology to distinguish between viable and nonviable cells to quantify cell kill following exposure to a drug of interest. With few exceptions, drug doses used in the assays are highly variable depending on tumor type and drug clas...