The objective of the present study is to formulate and evaluate roxithromycin tablets employing roxithromycin (ROX) solid dispersions. Dispersions of ROX in mannitol were prepared by different techniques like physical mixing, melting method, melt solvent method, kneading technique and common solvent method with drug and carrier ratio of 1:1, 1:2, 1:4 and 1:9. ROX tablets were formulated employi...

Present investigation describes preparation of microspheres by solvent evaporation and W/O emulsion solvent evaporation methods followed by in vitro characterization of microspheres to evaluate the effect of method of preparation on physical properties and drug release profile of microspheres. The microspheres were found to be discrete, spherical with free flowing properties. The morphology (Sc...

The reliance of the world economies on the use of fossil fuels (i.e. coal, natural gas and oil) as primary source of energy, have contributes to the high emission of CO2 in atmosphere. One of the promising way to mitigate the CO2 emission is by implemented Post Combustion Carbon Capture (PCCC) through absorption process. PCCC by amines based solvent is a method to remove the carbon dioxide from...

Atomistic simulations are used to characterize the molecular dynamics (MD) of alkyl chains with different functionalizations in different water/acetonitrile mixtures (80/20 and 50/50). Starting from fully equilibrated solvent systems (flat density profile for both components), microheterogeneous structuring of the solvent in the chromatographic system is found for both mixtures. Depending on th...

The controlled preparation of different crystal morphologies with varying preferential orientation with respect to the substrate is of crucial importance in many fields of applications. In this work, the controlled preparation of different phenytoin morphologies and the dependency of the preferential orientation of those crystallites is related with the preparation method (solvent annealing vs ...

A gel is an aggregate of polymers and solvent molecules. The polymers crosslink into a three-dimensional network by strong chemical bonds, and enable the gel to retain its shape after a large deformation. The solvent molecules, however, interact among themselves and with the network by weak physical bonds, and enable the gel to be a conduit of mass transport. The time-dependent concurrent proce...

A complete description of the Supercritical Antisolvent Process requires the modelling of several complex physical phenomena such as heat and mass transfer, hydrodynamic, phase equilibria of ternary mixtures, and nucleation /growth of the specie to be precipitated; moreover, the description should also account for the biphasic case, where the jet of organic solvent breaks up as droplets. As a f...

A statistical thermodynamic development is given of a new implicit solvent model that avoids the traditional system size limitations of computer simulation of macromolecular solutions with periodic boundary conditions. This implicit solvent model is based upon the quasi-chemical approach, distinct from the common integral equation trunk of the theory of liquid solutions. The idea is geometrical...

One important class of hydrogels based on natural polymers is the Glycosaminoglycan (GAG)-based hydrogels. In hydrogels biomaterial science, the mathematical modeling and computer simulation plays a complementary interpretative role in deciphering the complex physical/chemical and biological properties of this class of substances. Aim: the molecular modeling studies presented here aimed the inf...

Water-mediated interactions play critical roles in biomolecular recognition processes. Explicit solvent molecular dynamics (MD) simulations and the variational implicit-solvent model (VISM) are used to study those hydration properties during binding for the biologically important p53/MDM2 complex. Unlike simple model solutes, in such a realistic and heterogeneous solute-solvent system with both...