نتایج جستجو برای: phosphodi esterase inhibitors
تعداد نتایج: 195342 فیلتر نتایج به سال:
The ges-1 gene of the nematode Caenorhabditis elegans codes for a nonspecific carboxylesterase that is expressed only in the intestinal lineage. This esterase has turned out to be a convenient biochemical marker for lineage-specific differentiation. In the present paper, we describe the production of several C. elegans strains that lack detectable activity of the ges-1 esterase. To isolate thes...
Juvenile hormone (JH) undergoes metabolic degradation by two major pathways involving JH esterase and JH epoxide hydrolase (EH). While considerable effort has been focussed on the study of JH esterase and the development of inhibitors for this enzyme, much less has been reported on the study of JH-EH. In this work, the asymmetric synthesis of two classes of inhibitors of recombinant JH-EH from ...
Objective: The purpose of the work was to investigate new synthetic compounds imidazolinone-based sulfonamide derivatives as potent and selective enyzme inhibitors. A number synthesized their inhibitory action against acetylcholine esterase (AChE), human (h) carbonic anhydrase (CA) isoforms I II were investigated. Material Method: identity has been confirmed by HRMS, 1H NMR, 13C NMR. pharmacolo...
We report the use of three glycosidase inhibitors, the bean polygalacturonase inhibiting protein 2 (PvPGIP2), the kiwi pectin methyl esterase inhibitor (AcPMEI), and the Triticum aestivum xylanase inhibitor III (TAXI-III), to control leaf blotch and Fusarium Head Blight (FHB) symptoms caused by the fungal pathogens Bipolaris sorokiniana and Fusarium graminearum. We produced transgenic durum whe...
The first component of human complement (C’l) has been reported to exist in serum as a proenzyme which can be activated by antigen-antibody aggregates (l-5), plasmin (1, B), and, in a partially purified state, by autocatalysis (6, 7) to an enzyme, C’l-e&erase, capable of hydrolyzing certain synthetic amino acid esters, notably N-acetyl-L-tyrosine ethyl ester (6-8), and interacting with the four...
During long-term incubation of human peripheral blood lym phocytes with phytohemagglutinin (PHA), adenosine cyclic 3': 5'-monophosphate (cyclic AMP) phosphodiesterase increases about 5-fold and guanosine cyclic 3':S'-monophosphate (cyclic GMP) phosphodiesterase increases about i 0-fold in specific activity. Under similar conditions, there is little change in either basal or fluoride-stimulated ...
Congenital myasthenic syndromes (CMS) are clinically and genetically heterogeneous inherited disorders characterized by impaired neuromuscular transmission. Mutations in the acetylcholinesterase (AChE) collagen-like tail subunit gene (COLQ) cause synaptic basal-lamina associated CMS with end-plate AChE deficiency. Here we present the clinical and molecular genetic findings of 22 COLQ-mutant CMS...
C1 esterase inhibitor (Berinert®) is generally used to treat severe attack of hereditary angioedema. We describe here the case of a patient who presented with a severe angioedema induced by angiotensin-converting enzyme inhibitors (ACEIs) endangering her life. It could be successfully treated with that medicine.
the study has strived to compare the leucocyte-esterase stripe activity on sputum samples with gram-stained direct smear microscopy. this is for the demonstration of white blood cells (wbcs) and so to develop a simple method for selecting suitable sputum samples for cultural examination and laboratory diagnosis. . a total of 17(34.0%) out of 50 samples studied were shown to be unsuitable for mi...
containing 1 ml. 15 % glycerol solution, 1-0 ml. 0-1 M-sodium acetate, 0-5 ml. 0-3 M-bicarbonate solution and 0 5 ml. of the enzyme solution. Occurrence of the back reaction would have given rise to an uptake of C02 from the system, but in fact no such uptake was observed. Under these conditions, therefore, no back reaction takes place, so that the incompleteness ofthe de-esterification cannot ...
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